Lipoxins and aspirin-triggered lipoxins have emerged as important factors in anti-inflammatory and proresolution pathways, the absence of which might cause chronic inflammation. The newly discovered resolvins and protectins, derived from omega-3 polyunsaturated fatty acids, are also potent locally acting agonists of endogenous anti-inflammation, and promote resolution. The functions of these lipid mediators, and their potential beneficial use in rheumatoid arthritis, are outlined in this Review.
- Stephanie Yacoubian
- Charles N Serhan
