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Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation

Here, van der Lans et al describe an antigen-agnostic approach to identify antibodies against Klebsiella pneumoniae. Functional analysis of these antibodies indicates that their capacity to activate complement depends on their antigenic target.

Sjors P. A. van der Lans
Bart W. Bardoel
Suzan H. M. Rooijakkers
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin

Angelino T. Tromp
Michiel Van Gent
András N. Spaan
Amendments and Corrections03 Sept 2018
Nature Microbiology

Volume: 3, P: 1187
Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin

Human CD45 serves as a receptor for the Staphylococcus aureus Panton–Valentine leukocidin (PVL) F-component LukF-PV and contributes to the species specificity behind PVL intoxication of human immune cells.

Angelino T. Tromp
Michiel Van Gent
András N. Spaan
Research07 May 2018
Nature Microbiology

Volume: 3, P: 708-717
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors

In this Review, Spaan, van Strijp and Torres discuss the implications of the identification of the cellular receptors for theStaphylococcus aureusbi-component leukocidins, the mechanisms of action of the leukocidins, their diverse roles during pathogenesis and their potential as targets for therapeutic interventions.

András N. Spaan
Jos A. G. van Strijp
Victor J. Torres
Reviews19 Apr 2017
Nature Reviews Microbiology

Volume: 15, P: 435-447
A refined localization of two deleted regions in chromosome 6q associated with salivary gland carcinomas

Lurdes Queimado
António Reis
Leonor Parreira
Research21 Jan 1998
Oncogene

Volume: 16, P: 83-88
Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations

J Gudmundsson
RB Barkardottir
S Ingvarsson
Research01 Sept 1995
British Journal of Cancer

Volume: 72, P: 696-701
Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Frerich M. Masson
Salvör Káradóttir
Bart W. Bardoel
ResearchOpen Access05 Sept 2024
Scientific Reports

Volume: 14, P: 1-15
Dietary assessment in elderly people: experiences gained from studies in the Netherlands

J H M de Vries
L C P G M de Groot
W A van Staveren
Research04 Feb 2009
European Journal of Clinical Nutrition

Volume: 63, P: S69-S74
Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13

A-M Cleton-Jansen
N Collins
MR Stratton
Research01 Nov 1995
British Journal of Cancer

Volume: 72, P: 1241-1244
Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing

Sjors P. A. van der Lans
Manon Janet-Maitre
Bart W. Bardoel
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-13
Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity

Sebastian Virreira Winter
Arturo Zychlinsky
Bart W. Bardoel
ResearchOpen Access12 Apr 2016
Scientific Reports

Volume: 6, P: 1-9
Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations

A Rashid
J-S Wang
J D Groopman
ResearchOpen Access26 Mar 1999
British Journal of Cancer

Volume: 80, P: 59-66
Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids

Cayetano Pleguezuelos-Manzano
Wouter A. G. Beenker
Jeroen den Hertog
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Remy M. Muts
Maurits A. den Boer
Dani A. C. Heesterbeek
ResearchOpen Access01 Nov 2023
Scientific Reports

Volume: 13, P: 1-12
Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients

M J van Belzen
B P C Koeleman
C Wijmenga
Research11 Mar 2004
Genes & Immunity

Volume: 5, P: 215-220
Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1

Elena Boero
Ronald D. Gorham Jr.
Suzan H. M. Rooijakkers
ResearchOpen Access06 Jan 2023
Scientific Reports

Volume: 13, P: 1-17
An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia

B J Jungerius
M L C Hoogendoorn
R J Sinke
Research25 Sept 2007
Molecular Psychiatry

Volume: 13, P: 1060-1068

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Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation

Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin

Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin

Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors

A refined localization of two deleted regions in chromosome 6q associated with salivary gland carcinomas

Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations

Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Dietary assessment in elderly people: experiences gained from studies in the Netherlands

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing

Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity

Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations

Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids

Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients

Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1

An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia

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