Hematopoietic stem cells (HSCs) can self-renew and potentially differentiate into all types of hematopoietic and immune-system cells. HSC transplantation for the treatment of autoimmune diseases aims to ablate and reset the dysregulated immune system. There are several critical issues, however, such as optimal patient selection and conditioning regimens, to consider before this technique can be more widely applied to the treatment of patients with immune-mediated disease.
- Nikolay P Nikolov
- Steven Z Pavletic
