Nature Search

Signal-sequence induced conformational changes in the signal recognition particle

The signal recognition particle plays a key role in the co-translational protein targeting of membrane and secretory proteins. Here the authors report a crystal structure of the ternary SRP complex in signal sequence bound and unbound forms, providing insight into how signal sequence binding is coupled to SRP receptor interaction.

Tobias Hainzl
A. Elisabeth Sauer-Eriksson
ResearchOpen Access08 Jun 2015
Nature Communications

Volume: 6, P: 1-7
Cyclical geothermal unrest as a precursor to Iceland’s 2021 Fagradalsfjall eruption

Ingression of magmatic gas into a geothermal aquifer generated cyclical deformation and primed the system for the 2021 Fagradalsfjall eruption, Iceland, according to a catalogue of 39,500 precursory earthquakes combined with a poroelastic model.

Ólafur G. Flóvenz
Rongjiang Wang
Claus Milkereit
Research02 May 2022
Nature Geoscience

Volume: 15, P: 397-404
Structural basis of signal-sequence recognition by the signal recognition particle

The signal sequence on nascent peptides is recognized by the signal recognition particle (SRP), with subsequent targeting of the SRP-ribosomal nascent complex to the membrane. The structure of a signal sequence bound to the core SRP is presented, revealing structural changes in the SRP upon signal sequence binding.

Tobias Hainzl
Shenghua Huang
A Elisabeth Sauer-Eriksson
Research20 Feb 2011
Nature Structural & Molecular Biology

Volume: 18, P: 389-391
Structure of the SRP19–RNA complex and implications for signal recognition particle assembly

Tobias Hainzl
Shenghua Huang
A. Elisabeth Sauer-Eriksson
Research05 Jun 2002
Nature

Volume: 417, P: 767-771
On catching the preparatory phase of damaging earthquakes: an example from central Italy

Matteo Picozzi
Antonio G. Iaccarino
Dino Bindi
ResearchOpen Access01 Sept 2023
Scientific Reports

Volume: 13, P: 1-16
A reversible gene trap collection empowers haploid genetics in human cells

A collection of single-gene-mutant human cells is described. This growing resource is based on gene-trap mutagenesis of a near-haploid human cell line and covers almost 3,500 human genes.

Tilmann Bürckstümmer
Carina Banning
Sebastian M B Nijman
Research25 Aug 2013
Nature Methods

Volume: 10, P: 965-971
Improvements to seismicity forecasting based on a Bayesian spatio-temporal ETAS model

Hossein Ebrahimian
Fatemeh Jalayer
Hamid Zafarani
ResearchOpen Access05 Dec 2022
Scientific Reports

Volume: 12, P: 1-27
Thermal remote sensing reveals communication between volcanoes of the Klyuchevskoy Volcanic Group

Diego Coppola
Marco Laiolo
Thomas R. Walter
ResearchOpen Access22 Jun 2021
Scientific Reports

Volume: 11, P: 1-16
Author Correction: Thermal remote sensing reveals communication between volcanoes of the Klyuchevskoy Volcanic Group

Diego Coppola
Marco Laiolo
Thomas R. Walter
Amendments and CorrectionsOpen Access17 Sept 2021
Scientific Reports

Volume: 11, P: 1
Dike intrusions during rifting episodes obey scaling relationships similar to earthquakes

Passarelli L.
Rivalta E.
Shuler A.
ResearchOpen Access28 Jan 2014
Scientific Reports

Volume: 4, P: 1-7
Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19^ARF/p53 axis in hematopoiesis, early T-cell development and tissue differentiation

M Gatzka
A Tasdogan
K Scharffetter-Kochanek
ResearchOpen Access23 Jan 2015
Cell Death & Differentiation

Volume: 22, P: 1451-1462
Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade

E M Grössinger
L Weiss
H H Kerschbaum
CorrespondenceOpen Access20 Jan 2014
Leukemia

Volume: 28, P: 954-958

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