Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. Kathryn Holt and colleagues now compare whole-genome sequences of 19 Typhi isolates dispersed throughout the phylogenetic tree of this pathogen, revealing notably little evidence of purifying selection, antigenic variation or recombination between isolates.
- Kathryn E Holt
- Julian Parkhill
- Gordon Dougan
