GlutathioneS-transferases protect cells from toxic electrophilic compounds, including potential carcinogens, by catalyzing their conjugation to glutathione. These enzymes are found in both kidney and urothelial tissue. In this Review, Simic and colleagues discuss the relationships between enzyme polymorphism, altered expression, susceptibility to kidney and bladder tumors, and resistance to chemotherapy.
- Tatjana Simic
- Ana Savic-Radojevic
- Jasmina Mimic-Oka
