Microdeletions of the chromosome locus 22q11.2 are linked to a variety of mental and neurological disorders in human, including schizophrenia. Using a mouse strain carrying a synthenic microdeletion, Mukai et al. show dendritic spine defects associated with the hemizygous loss of the 22q11.2 locus, which includes the gene responsible for neuronal protein palmitoylation.
- Jun Mukai
- Alefiya Dhilla
- Joseph A Gogos
