In this Review, Heiko Lickert and colleagues discuss β-cell heterogeneity, placing a particular emphasis on the role of islet architecture in defining phenotypic and functional plasticity among β cells. The potential to exploit β-cell heterogeneity and plasticity for diagnostic and therapeutic purposes in the context of regenerative therapies for diabetes mellitus is also discussed.
- Sara S. Roscioni
- Adriana Migliorini
- Heiko Lickert