This Consensus Statement uses available mechanistic knowledge on pharmaceutical, chemical, physical and biological agents to identify the key characteristics (KCs) of metabolism-disrupting agents (MDAs). Examples demonstrating the use of these KCs to characterize the toxicity of various agents are provided. Recommendations for assessing how previously untested chemicals might affect specific KCs are also outlined.
- Michele A. La Merrill
- Martyn T. Smith
- Bruce Blumberg
