Nature Search

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Rider, Grantham, Smith, Watson et al. integrate multiomic data from patients with psoriasis using dimensionality reduction and machine learning techniques. This approach identifies biological relationships between genetic background, clinical features and disease severity, providing insight into disease variability across individuals.

Ashley Rider
Henry J. Grantham
Paola Di Meglio
ResearchOpen Access21 Jan 2026
Communications Medicine

Volume: 6, P: 1-21
Restriction fragment length polymorphism of the L-myc gene is not a prognostic factor in bladder cancer patients

M J Ejarque
M Vicente
G Chéchile
ResearchOpen Access12 Mar 1999
British Journal of Cancer

Volume: 79, P: 1855-1858
Palaeoecological data indicates land-use changes across Europe linked to spatial heterogeneity in mortality during the Black Death pandemic

Historical accounts of the mortality outcomes of the Black Death plague pandemic are variable across Europe, with much higher death tolls suggested in some areas than others. Here the authors use a ‘big data palaeoecology’ approach to show that land use change following the pandemic was spatially variable across Europe, confirming heterogeneous responses with empirical data.

A. Izdebski
P. Guzowski
A. Masi
ResearchOpen Access10 Feb 2022
Nature Ecology & Evolution

Volume: 6, P: 297-306
Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age

Skewing of X chromosome inactivation (XCI) occurs when the silencing of one parental X chromosome is non-random. Here, Zito et al. report XCI patterns in lymphoblastoid cell lines, blood, subcutaneous adipose tissue samples and skin samples of monozygotic and dizygotic twins and find XCI skew to associate with tissue and age.

Antonino Zito
Matthew N. Davies
Kerrin S. Small
ResearchOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-11
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Succinate is a signaling metabolite sensed extracellularly by SUNCR1. Fernandez-Veledo and colleagues show that activation of SUCNR1 promotes an anti-inflammatory phenotype in adipose-tissue macrophages in lean mice and people.

Noelia Keiran
Victoria Ceperuelo-Mallafré
Sonia Fernández-Veledo
Research08 Apr 2019
Nature Immunology

Volume: 20, P: 581-592
Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells

Miriam Ejarque
Victoria Ceperuelo-Mallafré
Sonia Fernández-Veledo
ResearchOpen Access27 Sept 2018
International Journal of Obesity

Volume: 43, P: 1256-1268
Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas

G. Pujadas
S. Cervantes
R. Gasa
ResearchOpen Access14 Jan 2016
Scientific Reports

Volume: 6, P: 1-15
Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity

S Carujo
J M Estanyol
M J Pujol
Research13 Feb 2006
Oncogene

Volume: 25, P: 4033-4042

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Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Restriction fragment length polymorphism of the L-myc gene is not a prognostic factor in bladder cancer patients

Palaeoecological data indicates land-use changes across Europe linked to spatial heterogeneity in mortality during the Black Death pandemic

Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells

Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas

Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity

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