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Showing 1–2 of 2 results
Advanced filters: Author: A. Karagiannopoulos Clear advanced filters

  • Single cell transcriptomics can be used to identify genes associated with type 2 diabetes (T2D) and computational models can be used to identify gene networks. Here the authors identify networks of dysregulated genes in T2D and the biological processes involved, further demonstrating the functional context of the identified genes.

    • J. A. Martínez-López
    • A. Lindqvist
    • N. Wierup
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Type 2 diabetes (T2D) is characterized by hyperglycemia caused by insufficient insulin release from pancreatic islets, often in combination with insulin resistance. Here the authors present an epigenetic case-control study in human pancreatic islets revealing changes that contribute to type 2 diabetes development, e.g., epigenetic downregulation of RHOT1.

    • Tina Rönn
    • Jones K. Ofori
    • Charlotte Ling
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21