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Showing 1–7 of 7 results
Advanced filters: Author: A. Lavens Clear advanced filters

  • Evolution- and structure-guided mutagenesis allows elucidation of the solution NMR structure of the N-terminal domain of APOBEC3G. Mapping of HIV-1 Vif binding to the APOBEC3G NTD reveals an interaction interface distinct from those in other APOBEC3 proteins.

    • Takahide Kouno
    • Elizabeth M Luengas
    • Hiroshi Matsuo
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 485-491

  • Metallo-β-lactamases cleave β-lactam moiety of many broadly used antibiotics. Here the authors captured mechanistic details of the enzyme catalyzed reaction using time-resolved xray synchrotron serial crystallography.

    • M. Wilamowski
    • D. A. Sherrell
    • A. Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bound inhibitors, which is of interest for further structure-based drug design efforts.

    • Jerzy Osipiuk
    • Saara-Anne Azizi
    • Andrzej Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Understanding mechanisms of PLpro substrate selectivity offers new ways to decouple substrate activities and will inform new therapeutic strategies. Here, the authors use multi-disciplinary approaches to uncover how PLpro from SARS-CoV-2 can discriminate between different substrates.

    • Pawel M. Wydorski
    • Jerzy Osipiuk
    • Lukasz A. Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • 2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is known to catalyze the condensation of formyl-CoA with aldehydes or ketones, however, the mechanism of one-carbon elongation biochemistry is not well understood. Here, the authors report the structures of enzymes in complex with co-factors, substrates, and products, revealing key intermediates and the C-terminal active site region, and distinguishing them from related sub-families.

    • Youngchang Kim
    • Seung Hwan Lee
    • Andrzej Joachimiak
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-10

  • Youngchang Kim, Jacek Wower, and colleagues explore the sequence specificity, metal ion dependence and catalytic mechanism of the Nsp15 endoribonuclease NendoU from SARS-CoV-2. The authors also solve five new crystal structures of the enzyme in complex with 5’UMP, 3’UMP, 5’cGpU, uridine 2′,3′-vanadate (transition state analog) and Tipiracil (uracil mimic), and demonstrate that Tipiracil inhibits SARS-CoV-2 Nsp15 by interacting with the uridine binding pocket in the enzyme’s active site.

    • Youngchang Kim
    • Jacek Wower
    • Andrzej Joachimiak
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11