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Showing 151–200 of 310 results

Advanced filters: Author: A. M. Soderberg Clear advanced filters

Thermo-mechanical contact problems and elastic behaviour of single and double sides functionally graded brake disks with temperature-dependent material properties

Mehdi Bayat
Ibrahim M. Alarifi
Amin Asadi
ResearchOpen Access25 Oct 2019
Scientific Reports

Volume: 9, P: 1-16
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

One of two papers showing that delta-like 4/Notch signalling limits angiogenic sprouting and branching by regulating tip cell formation.

Mats Hellström
Li-Kun Phng
Christer Betsholtz
Research28 Jan 2007
Nature

Volume: 445, P: 776-780
The use of an all oral chemotherapy (idarubicin and etoposide) in the treatment of acute myeloid leukaemia in the elderly: a report of toxicity and efficacy

GH Jackson
PRA Taylor
SJ Proctor
Research01 Aug 1997
Leukemia

Volume: 11, P: 1193-1196
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome

J.D. Carpten
C.M. Robbins
M.R. Hobbs
Research18 Nov 2002
Nature Genetics

Volume: 32, P: 676-680
A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma patients

R L Huuhtanen
T A Wiklund
L C Andersson
ResearchOpen Access29 Oct 1999
British Journal of Cancer

Volume: 81, P: 1017-1021
A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort

Sofia Christakoudi
Konstantinos K. Tsilidis
Elio Riboli
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-15
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Abnormal levels of Aβ42 in the cerebrospinal fluid occur prior to a positive amyloid PET scan in the brain of individuals with Alzheimer’s disease and here the authors use this temporal pattern to identify individuals with very early stage AD. They show that Aβ fibrils start to accumulate in some of the regions of the default mode network and affect brain connectivity before neurodegeneration occurs.

Sebastian Palmqvist
Michael Schöll
Oskar Hansson
ResearchOpen Access31 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Delayed but effective induction of mucosal memory immune responses against genital HSV-2 in the absence of secondary lymphoid organs

K L Roth
S Bhavanam
C Kaushic
Research20 Jun 2012
Mucosal Immunology

Volume: 6, P: 56-68
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer

Identification of a DNA-damage signature induced by colibactin, a toxin expressed by some strains of Escherichia coli, is enriched in human colorectal cancers.

Paulina J. Dziubańska-Kusibab
Hilmar Berger
Thomas F. Meyer
Research01 Jun 2020
Nature Medicine

Volume: 26, P: 1063-1069
Evidence for two types of brown adipose tissue in humans

Brown fat is a thermogenically active organ that burns energy instead of storing it and has been the focus of intense research recently in the hopes of harnessing this activity to combat obesity. Sven Enerbäck and his colleagues now show that human neonates possess a classical form of this type of fat, suggesting hope that its expansion in adults may indeed be an avenue of therapy to treat obesity.

Martin E Lidell
Matthias J Betz
Sven Enerbäck
Research21 Apr 2013
Nature Medicine

Volume: 19, P: 631-634
Slowly fading super-luminous supernovae that are not pair-instability explosions

Observations of two slow-to-fade super-luminous supernovae are reported; both show relatively fast rise times and blue colours, which are incompatible with pair-instability models.

M. Nicholl
S. J. Smartt
C. Waters
Research16 Oct 2013
Nature

Volume: 502, P: 346-349
Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Genetic risk scores derived from GWAS of psychotic disorders are greater in creative professionals unaffected by psychosis. This association cannot be explained by shared environment or education. Thus, a shared genetic architecture underlies the propensity for creativity and psychosis.

Robert A Power
Stacy Steinberg
Kari Stefansson
Research08 Jun 2015
Nature Neuroscience

Volume: 18, P: 953-955
Glucose Production Rate in Extremely Immature Neonates (<28 Weeks) Studied by Use of Deuterated Glucose

A Sunehag
U Ewald
J Gustafsson
Research01 Feb 1993
Pediatric Research

Volume: 33, P: 97-100
Risk of cytomegalovirus infection after peripheral blood stem cell transplantation

H Sakuma
M Hosoya
H Suzuki
Research01 Jan 1997
Bone Marrow Transplantation

Volume: 19, P: 49-53
Changes in BMI modulate age-associated changes in sex hormone binding globulin and total testosterone, but not bioavailable testosterone in young adult men: the CARDIA Male Hormone Study

S M Gapstur
P Kopp
K Liu
Research12 Sept 2006
International Journal of Obesity

Volume: 31, P: 685-691
Hundreds of variants clustered in genomic loci and biological pathways affect human height

This very large genome-wide association study identifies hundreds of new genetic variants influencing adult height in at least 180 loci enriched for genes involved in skeletal growth defects. The results show that the likely causal gene is often located near the most strongly associated variant, that many loci have multiple independently associated variants and that associated variants are enriched for likely functional effects on genes.

Hana Lango Allen
Karol Estrada
Joel N. Hirschhorn
Research29 Sept 2010
Nature

Volume: 467, P: 832-838
Comparison of various surrogate obesity indicators as predictors of cardiovascular mortality in four European populations

X Song
P Jousilahti
Q Qiao
Research23 Oct 2013
European Journal of Clinical Nutrition

Volume: 67, P: 1298-1302
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma

Berglind O. Einarsdottir
Joakim Karlsson
Jonas A. Nilsson
ResearchOpen Access24 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-12
Plasma leptin is independently associated with the intima-media thickness of the common carotid artery

M Ciccone
R Vettor
G De Pergola
Research06 Jul 2001
International Journal of Obesity

Volume: 25, P: 805-810
Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study

A Shah
A Hernandez
A M Kanaya
Research23 Aug 2011
International Journal of Obesity

Volume: 36, P: 810-816
Plasma neurofilament light chain concentration is increased in anorexia nervosa

Ida A. K. Nilsson
Vincent Millischer
Mikael Landén
ResearchOpen Access01 Aug 2019
Translational Psychiatry

Volume: 9, P: 1-6
Cardiac biomarkers for detection of coronary artery disease in the community

Lars Lind
Joakim Alfredsson
Gunnar Engström
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease

María-Salud García-Ayllón
Inmaculada Lopez-Font
Javier Sáez-Valero
ResearchOpen Access30 May 2017
Scientific Reports

Volume: 7, P: 1-7
Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface

Christopher A. G. Söderberg
Cecilia Månsson
Cecilia Emanuelsson
ResearchOpen Access26 Mar 2018
Scientific Reports

Volume: 8, P: 1-15
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

Age-dependent epithelial expression of the innate immune receptor TLR5 in the gut of newborn mice selects against the presence of flagellated bacteria and influences microbiota composition throughout life.

Marcus Fulde
Felix Sommer
Mathias W. Hornef
Research08 Aug 2018
Nature

Volume: 560, P: 489-493
In situ quantification of HER2–protein tyrosine kinase 6 (PTK6) protein–protein complexes in paraffin sections from breast cancer tissues

M Aubele
M Spears
J M S Bartlett
ResearchOpen Access10 Aug 2010
British Journal of Cancer

Volume: 103, P: 663-667
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

Robert R Graham
Sergey V Kozyrev
Marta E Alarcón-Riquelme
Research16 Apr 2006
Nature Genetics

Volume: 38, P: 550-555
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Christer Betsholtz, Christine Klein, Maria Sobrido and colleagues report the identification of mutations in the gene encoding PDGF-B that cause idiopathic basal ganglia calcification. They also show that mice carrying hypomorphic Pdgfb alleles develop brain calcifications.

Annika Keller
Ana Westenberger
Joao R M Oliveira
Research04 Aug 2013
Nature Genetics

Volume: 45, P: 1077-1082
Multiplexed chromatin immunoprecipitation sequencing for quantitative study of histone modifications and chromatin factors

MINUTE-ChIP is a multiplexed chromatin immunoprecipitation and sequencing method that measures global and locus-specific changes in histone modification patterns and chromatin factor binding across multiple samples and conditions.

Banushree Kumar
Carmen Navarro
Simon J. Elsässer
Protocols03 Oct 2024
Nature Protocols

Volume: 20, P: 779-809
The gut microbiota — masters of host development and physiology

The gut microbiota, traditionally studied in the context of disease, has emerged as a key regulator during normal homeostasis. Here, Sommer and Bäckhed discuss how the gut microbiota promotes the development and homeostasis of the immune system and orchestrates several aspects of human physiology, including tissue morphogenesis, metabolism and even behaviour.

Felix Sommer
Fredrik Bäckhed
Reviews25 Feb 2013
Nature Reviews Microbiology

Volume: 11, P: 227-238
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

The zebrafish cloche gene is required for the formation of most endothelial and haematopoietic cells, however, it has been difficult to isolate; this study reveals that cloche encodes a PAS-domain-containing bHLH transcription factor, and a mammalian orthologue can partially rescue cloche mutants, indicating a possible conserved role in mammals.

Sven Reischauer
Oliver A. Stone
Didier Y. R. Stainier
Research13 Jul 2016
Nature

Volume: 535, P: 294-298
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

John Chambers and colleagues report a genome-wide association study for markers of liver function. They identify 42 loci associated with concentrations of one or more liver enzymes in plasma, and use a range of functional genomic analyses to suggest candidate genes at these loci.

John C Chambers
Weihua Zhang
Jaspal S Kooner
Research16 Oct 2011
Nature Genetics

Volume: 43, P: 1131-1138
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

The Coronary Artery Disease Genetics Consortium report a meta-analysis of genome-wide association studies for coronary artery disease (CAD) in discovery and replication cohorts including both European and South Asian studies. They identify five loci newly associated with CAD.

John F Peden
Jemma C Hopewell
Sonia S Anand
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 339-344
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić
Pollyanna A. Goh
Dean Nižetić
ResearchOpen Access10 Jul 2020
Molecular Psychiatry

Volume: 26, P: 5766-5788
Replication stress links structural and numerical cancer chromosomal instability

A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes (PIGN, MEX3C and ZNF516) encoded on chromosome 18q are identified, the loss of which leads to DNA replication stress, resulting in structural and numerical chromosome segregation errors, which are shown to be identical to phenotypes seen in CIN cells.

Rebecca A. Burrell
Sarah E. McClelland
Charles Swanton
Research27 Feb 2013
Nature

Volume: 494, P: 492-496
A functional variant in the CFI gene confers a high risk of age-related macular degeneration

Johannes van de Ven and colleagues report a rare missense mutation in CFI encoding a p.Gly119Arg substitution that confers a high risk of AMD. Sera from AMD cases carrying the p.Gly119Arg variant mediate the degradation of C3b at a significantly lower level than sera from AMD cases without the CFI variant.

Johannes P H van de Ven
Sara C Nilsson
Anneke I den Hollander
Research19 May 2013
Nature Genetics

Volume: 45, P: 813-817
Association analyses based on false discovery rate implicate new loci for coronary artery disease

Hugh Watkins and colleagues meta-analyze data from the UK Biobank along with recent genome-wide association studies for coronary artery disease. They identify 13 new loci that were genome-wide significant and 243 loci at a 5% false discovery rate.

Christopher P Nelson
Anuj Goel
Panos Deloukas
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1385-1391
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

Colonization of germ-free mice with microbiota promotes vascular growth in the small intestine through a mechanism involving tissue factor, PAR1 and Ang1.

Christoph Reinhardt
Mattias Bergentall
Fredrik Bäckhed
Research11 Mar 2012
Nature

Volume: 483, P: 627-631
Genome-wide association study identifies 74 loci associated with educational attainment

A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational attainment, highlights candidate genes and pathways for further study.

Aysu Okbay
Jonathan P. Beauchamp
Daniel J. Benjamin
Research11 May 2016
Nature

Volume: 533, P: 539-542
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

Stella Karsten
Roland Fiskesund
Ulrika Warpman Berglund
Research27 Aug 2021
Cell Death & Differentiation

Volume: 29, P: 246-261
Relationship between body mass index and mortality among Europeans

X Song
J Pitkäniemi
Q Qiao
Research10 Aug 2011
European Journal of Clinical Nutrition

Volume: 66, P: 156-165
Epstein–Barr virus expression in Hodgkin’s disease in relation to patient characteristics, serum factors and blood lymphocyte function

U Axdorph
A Porwit-MacDonald
M Björkholm
ResearchOpen Access12 Nov 1999
British Journal of Cancer

Volume: 81, P: 1182-1187
Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma

Berglind O. Einarsdottir
Joakim Karlsson
Jonas A. Nilsson
Amendments and CorrectionsOpen Access06 Feb 2020
Cell Death & Disease

Volume: 11, P: 1
Niche specialization of novel Thaumarchaeota to oxic and hypoxic acidic geothermal springs of Yellowstone National Park

Jacob P Beam
Zackary J Jay
William P Inskeep
Research07 Nov 2013
The ISME Journal

Volume: 8, P: 938-951
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells

M Wade
Y C Li
G M Wahl
Research23 Jan 2012
Oncogene

Volume: 31, P: 4789-4797
Membrane estrogen receptor α signaling modulates the sensitivity to estradiol treatment in a dose- and tissue- dependent manner

Yiwen Jiang
Karin Horkeby
Marie K. Lagerquist
ResearchOpen Access03 Jun 2023
Scientific Reports

Volume: 13, P: 1-9
Radixin modulates the function of outer hair cell stereocilia

Sonal Prasad et al. identify several mutations in the radixin (RDX) gene that are associated with early-life hearing loss. Using a guinea pig model, they propose that radixin helps convert sound into electrical signals in the mature inner ear.

Sonal Prasad
Barbara Vona
Anders Fridberger
ResearchOpen Access23 Dec 2020
Communications Biology

Volume: 3, P: 1-15
Recent functional insights into the role of (p)ppGpp in bacterial physiology

In this Review, Gerdes and colleagues discuss the multifaceted alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) and their functions in the regulation of bacterial physiology, including their synthesis and degradation, as well as their role in transcriptional regulation, in GTP biosynthesis and in the formation of bacterial persisters.

Vasili Hauryliuk
Gemma C. Atkinson
Kenn Gerdes
Reviews08 Apr 2015
Nature Reviews Microbiology

Volume: 13, P: 298-309
Brown adipose tissue—a new role in humans?

Several independent studies have shown the presence of functional brown adipose tissue in adult humans. Its innate ability to expend energy via heat production is a feature that could be used to develop new regimens to treat obesity and type 2 diabetes mellitus. This Review outlines the current knowledge on the transcriptional regulation and development of brown adipose tissue and addresses possible targets that may be useful for the expansion and/or activation of brown adipose tissue by pharmacological means.

Martin E. Lidell
Sven Enerbäck
Reviews13 Apr 2010
Nature Reviews Endocrinology

Volume: 6, P: 319-325
Ethnic comparison of the association of undiagnosed diabetes with obesity

R Nyamdorj
J Pitkäniemi
Q Qiao
Research03 Nov 2009
International Journal of Obesity

Volume: 34, P: 332-339

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