Nature Search

JOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7

Si-rui Shen
Zhu-qi Huang
Guang Liang
Research20 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1275-1288
Methylation in Mycobacterium tuberculosis is lineage specific with associated mutations present globally

Jody Phelan
Paola Florez de Sessions
Taane G. Clark
ResearchOpen Access09 Jan 2018
Scientific Reports

Volume: 8, P: 1-7
Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications

This Review highlights the diversity in sequence composition of disease-related short tandem repeats. The authors discuss how to detect non-canonical motifs in repeat sequences from sequencing data and review the molecular and clinical consequences of sequence composition changes.

Indhu-Shree Rajan-Babu
Egor Dolzhenko
Jan M. Friedman
Reviews11 Mar 2024
Nature Reviews Genetics

Volume: 25, P: 476-499
Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

Fernanda Machado Santos-Almeida
Gean Domingos-Souza
Helio C. Salgado
ResearchOpen Access24 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism

A new mechanism that plants use to combat begomoviruses—one of the most pathogenic groups of plant viruses, causing severe disease in major crops worldwide—is uncovered: plants inhibit the transcription of genes associated with the translational apparatus, thus causing a general reduction in protein synthesis.

Cristiane Zorzatto
João Paulo B. Machado
Elizabeth P. B. Fontes
Research23 Feb 2015
Nature

Volume: 520, P: 679-682
Causes and consequences of insect decline in tropical forests

Insect biodiversity in tropical forests is poorly understood but is probably facing declines, with serious consequences for ecosystem functions and services. This Review describes the major threats to insect biodiversity, which include the effects of a burgeoning human population and of climate change. The authors further highlight the urgent need for greater efforts to measure and monitor insect biodiversity in the tropics and discuss emerging approaches to facilitate such studies.

Michael J. W. Boyle
Timothy C. Bonebrake
Louise A. Ashton
Reviews04 Apr 2025
Nature Reviews Biodiversity

Volume: 1, P: 315-331
Assessing synergy or antagonism for drug combinations

Angus Bell
Stella G. Machado
Correspondence01 Nov 2004
Nature Reviews Drug Discovery

Volume: 3, P: 982
Potential therapeutic applications of autophagy

The process of autophagy has recently sparked great interest as it is recognized to be involved in a wide range of diseases. The prospect of its manipulation for therapeutic purposes has led to the discovery of many exciting new potential drug targets.

David C. Rubinsztein
Jason E. Gestwicki
Daniel J. Klionsky
Reviews01 Apr 2007
Nature Reviews Drug Discovery

Volume: 6, P: 304-312
Restoration and management of an Indigenous aquaculture system helps mitigate climate change impacts to estuarine fisheries

Anne A. Innes-Gold
Kate Feloy
Lisa C. McManus
ResearchOpen Access30 Sept 2025
npj Ocean Sustainability

Volume: 4, P: 1-14
Is it time to replace BASDAI with ASDAS?

The ankylosing spondylitis disease activity score (ASDAS) is a measure of axial spondyloarthritis (SpA) disease activity endorsed by the Assessment of SpA International Society and Outcome Measures in Rheumatology. Accumulating evidence supports the utility of ASDAS in axial SpA. So, is it time to replace the Bath ankylosing spondylitis disease activity index (BASDAI)?

Pedro Machado
Robert Landewé
News & Views25 Jun 2013
Nature Reviews Rheumatology

Volume: 9, P: 388-390
Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil

The COVID-19 pandemic in Brazil is assessed using phylogenetic and phylogeographic analysis.

Marta Giovanetti
Svetoslav Nanev Slavov
Dimas Tadeu Covas
ResearchOpen Access18 Aug 2022
Nature Microbiology

Volume: 7, P: 1490-1500
Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative

Alexander G. S. Oldroyd
Jeffrey P. Callen
Rohit Aggarwal
Amendments and Corrections28 Mar 2024
Nature Reviews Rheumatology

Volume: 20, P: 315
Multiple karyotype differences between populations of the Hoplias malabaricus (Teleostei; Characiformes), a species complex in the gray area of the speciation process

Fernando H. S. Souza
Manolo F. Perez
Marcelo B. Cioffi
Research22 Jul 2024
Heredity

Volume: 133, P: 216-226
When ubiquitin meets ubiquitin receptors: a signalling connection

Pier Paolo Di Fiore
Simona Polo
Kay Hofmann
Reviews01 Jun 2003
Nature Reviews Molecular Cell Biology

Volume: 4, P: 491-497
Spinal shock and `brain death': Somatic pathophysiological equivalence and implications for the integrative-unity rationale

DA Shewmon
Research19 May 1999
Spinal Cord

Volume: 37, P: 313-324
Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

Miratul M. K. Muqit
Mel B. Feany
Reviews01 Mar 2002
Nature Reviews Neuroscience

Volume: 3, P: 237-243
Author Correction: Ongoing declines for the world’s amphibians in the face of emerging threats

Jennifer A. Luedtke
Janice Chanson
Simon N. Stuart
Amendments and CorrectionsOpen Access01 Dec 2023
Nature

Volume: 625, P: E2
Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases

Limbic-predominant age-related TDP43 encephalopathy (LATE) is a clinical entity characterized by amnestic dementia resembling Alzheimer disease. This Review focuses on the pathology, genetic risk factors and clinical features associated with pure LATE neuropathological change and LATE neuropathological change with coexisting pathologies.

Sukriti Nag
Julie A. Schneider
Reviews10 Aug 2023
Nature Reviews Neurology

Volume: 19, P: 525-541
Stem cells: The cell division

Oliver Brüstle fought for more than a decade to pursue and patent human embryonic stem-cell research in Germany. Now his efforts have backfired.

Alison Abbott
News14 Dec 2011
Nature

Volume: 480, P: 310-312
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP

Stella Victorelli
Hanna Salmonowicz
João F. Passos
Amendments and CorrectionsOpen Access02 Jan 2024
Nature

Volume: 625, P: E15
Genes and speciation

Chung-I Wu
Chau-Ti Ting
Reviews01 Feb 2004
Nature Reviews Genetics

Volume: 5, P: 114-122
Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

Henrique Machado et al. describe mutational mechanisms associated with MRSA vancomycin resistance in Staphylococcus aureus using adaptive laboratory evolution experiments focused on tolerance. Their results reveal environment-dependent mutational strategies to vancomycin tolerization and the impact of mutations in regulatory genes, providing insight into the development of antibiotic resistance under multiple conditions.

Henrique Machado
Yara Seif
Adam M. Feist
ResearchOpen Access25 Jun 2021
Communications Biology

Volume: 4, P: 1-12
Innate immune activation in neurodegenerative disease

In this Review, the authors discuss how innate immune mechanisms can contribute to the development of neurodegenerative disease. They suggest that both local and systemic inflammation can drive pathological microglial cell activity, thereby leading to neuronal cell dysfunction and disease.

Michael T. Heneka
Markus P. Kummer
Eicke Latz
Reviews25 Jun 2014
Nature Reviews Immunology

Volume: 14, P: 463-477
Radiocarbon dating of lead white: novel application in the study of polychrome sculpture

Sara Sá
Laura Hendriks
Irka Hajdas
ResearchOpen Access24 Jun 2021
Scientific Reports

Volume: 11, P: 1-14
Unveiling the menace of lampenflora to underground tourist environments

Rosangela Addesso
Daniela Baldantoni
Ana Z. Miller
ResearchOpen Access06 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Pluripotent stem cells in disease modelling and drug discovery

The use of cultured human pluripotent stem cells (PSCs) to model human diseases has revolutionized the ways in which we study monogenic, multigenic and epigenetic disorders, by overcoming some of the limitations of animal models. PSC-based disease models are generated using various strategies and can be used for the discovery of new drugs and therapies.

Yishai Avior
Ido Sagi
Nissim Benvenisty
Reviews28 Jan 2016
Nature Reviews Molecular Cell Biology

Volume: 17, P: 170-182
Thyroid hormone receptors and resistance to thyroid hormone disorders

Mutations in the genes that encode the thyroid hormone receptors (THRs),THRA and THRB, result in resistance to thyroid hormone disorders, RTHα and RTHβ, respectively. In this Review, the authors discuss mutations that have been identified in patients with RTH and mouse models of these disorders that have contributed to understanding the physiology and functions of THRs.

Tânia M. Ortiga-Carvalho
Aniket R. Sidhaye
Fredric E. Wondisford
Reviews19 Aug 2014
Nature Reviews Endocrinology

Volume: 10, P: 582-591
Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies

Here the authors have characterized the growth of 96 human gut bacteria on a range of defined media, providing valuable insights into their metabolic capabilities and unique media for future studies.

Melanie Tramontano
Sergej Andrejev
Kiran Raosaheb Patil
Research19 Mar 2018
Nature Microbiology

Volume: 3, P: 514-522
Sexual dimorphism in the aging kidney: differences in the nitric oxide system

Glomerular filtration rate usually decreases with advancing age as a result of structural and functional changes in the aging kidney, but women are substantially protected against the age-dependent decline in renal function. This sexual dimorphism is the product of differences in chromosomes, perinatal programming and gonadal hormones (sex steroids) that create sexual phenotype. In this Review, Chris Baylis focuses on the role of the sex steroids, with a particular emphasis on the effects of sex and age on the nitric oxide system.

Chris Baylis
Reviews02 Jun 2009
Nature Reviews Nephrology

Volume: 5, P: 384-396
An expanded lexicon for the ubiquitin code

Recent studies have expanded our understanding of the mechanisms and functions of ubiquitylation. Pathogens rewrite ubiquitylation to promote infection through unconventional ubiquitylation involving lipids and sugars, and structural studies have revealed that ubiquitin functions involve elaborate multivalent interactions that regulate transcription or protein degradation.

Ivan Dikic
Brenda A. Schulman
Reviews25 Oct 2022
Nature Reviews Molecular Cell Biology

Volume: 24, P: 273-287
Reprogramming patient-derived cells to study the epilepsies

In this Review article, Jack Parent and Stewart Anderson discuss the advantages and limitations of using patient-derived cells, such as induced pluripotent stem cells, to probe the mechanisms of epileptogenesis and disease progression. In addition, they look at potential therapeutic avenues, such as cell-replacement strategies, that may arise from this field.

Jack M Parent
Stewart A Anderson
Reviews24 Feb 2015
Nature Neuroscience

Volume: 18, P: 360-366
Detecting contract cheating through linguistic fingerprint

Mohammed Kutbi
Ali H. Al-Hoorie
Abbas H. Al-Shammari
ResearchOpen Access24 May 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-9
Nondestructive quantification of internal raster path for additively manufactured components via ultrasonic testing

Atik Amin
David A. Jack
Trevor J. Fleck
ResearchOpen Access19 May 2024
Scientific Reports

Volume: 14, P: 1-10
Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

Muscle stem cell quiescence in mice is maintained by a Notch–Collagen V–CALCR signalling pathway that is activated and sustained in a cell-autonomous fashion.

Meryem B. Baghdadi
David Castel
Philippos Mourikis
Research23 May 2018
Nature

Volume: 557, P: 714-718
MORPHINE: SITES OF ACTION IN GUANOSINE NUCLEOSIDE PATHWAY: 38

Major L Cohn
Faye A Eggerding
Stephan J Conn
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 750
Two commonly expanded CAG/CTG repeat loci: involvement in affective disorders?

K Lindblad
P-O Nylander
M Schalling
Research28 Sept 1998
Molecular Psychiatry

Volume: 3, P: 405-410
The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

Xueyuan Guo
Yanfang Ma
Genze Shao
ResearchOpen Access11 May 2024
npj Breast Cancer

Volume: 10, P: 1-14
Overlooking vegetation loss outside forests imperils the Brazilian Cerrado and other non-forest biomes

Polyanna da Conceição Bispo
Michelle C. A. Picoli
Celso H. L. Silva-Junior
Correspondence06 Nov 2023
Nature Ecology & Evolution

Volume: 8, P: 12-13
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
The controversial company using DNA to sketch the faces of criminals

Parabon Nanolabs shot to fame using DNA and genealogy analysis to solve cold cases. Then it hit a setback.

Carrie Arnold
News09 Sept 2020
Nature

Volume: 585, P: 178-181
Rare genetic variants and severe COVID-19 in previously healthy admixed Latin American adults

Gabriela Dias Rocha
Pablo Rafael Silveira Oliveira
Luydson Richardson Silva Vasconcelos
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Publisher Correction: Measuring the α-particle charge radius with muonic helium-4 ions

Julian J. Krauth
Karsten Schuhmann
Franz Kottmann
Amendments and CorrectionsOpen Access27 Feb 2021
Nature

Volume: 591, P: E18
How deep is your trust? A comparative user requirements’ analysis of automation in medical and mobility technologies

Sophia Hick
Hannah Biermann
Martina Ziefle
ResearchOpen Access08 Jan 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Pterosaur diversity and faunal turnover in Cretaceous terrestrial ecosystems in China

Xiaolin Wang
Alexander W. A. Kellner
Diogenes de Almeida Campos
Research06 Oct 2005
Nature

Volume: 437, P: 875-879
Relapsed chronic myeloid leukemia in accelerated phase 10 years after allogeneic bone marrow transplantation: full chimera reconversion with donor peripheral blood stem cells infusion

A Guimarães
A Machado
M Abecasis
Research10 Sept 1998
Bone Marrow Transplantation

Volume: 22, P: 595-597
828 ABNORMAL CARTILAGE COLLAGENS IN ACHONDROGENESIS II

William A Horton
Mirta A Machado
David R Eyre
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 248
Medieval forewarning of the 2004 Indian Ocean tsunami in Thailand

Kruawun Jankaew
Brian F. Atwater
Amy Prendergast
Research30 Oct 2008
Nature

Volume: 455, P: 1228-1231
Perceived usefulness and effectiveness of a MOOC on healthcare during the pandemic

José Miguel Padilha
Celeste Bastos
Margarida Abreu
ResearchOpen Access06 Jun 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-9
Recent Work of Geological Surveys

G. A. J. C.
News26 Dec 1907
Nature

Volume: 77, P: 183-186
Multiple system atrophy: insights into a rare and debilitating movement disorder

In this Review, Krismer and Wenning discuss the risk factors for and the clinical presentation and neuropathology of multiple system atrophy (MSA) — a devastating and fatal neurodegenerative disorder. They provide an overview of ongoing trials and international efforts to improve care in patients with MSA.

Florian Krismer
Gregor K. Wenning
Reviews17 Mar 2017
Nature Reviews Neurology

Volume: 13, P: 232-243

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