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Showing 1–5 of 5 results
Advanced filters: Author: A. Rouf Banday Clear advanced filters

  • A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform could be decreased by inducing skipping of APOBEC3B exon 5 in cells treated with SF3B1 inhibitor or splice-switching oligos.

    • A. Rouf Banday
    • Olusegun O. Onabajo
    • Ludmila Prokunina-Olsson
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16

  • Genetic and functional studies implicate allele-specific regulation of OAS1 splicing and nonsense-mediated decay in COVID-19 severity. The OAS1 risk haplotype is also associated with reduced SARS-CoV-2 clearance in a clinical trial with pegIFN-λ1.

    • A. Rouf Banday
    • Megan L. Stanifer
    • Ludmila Prokunina-Olsson
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1103-1116

  • Ludmila Prokunina-Olsson and colleagues report a fine-mapping and association analysis of germline variants in the APOBEC3 region associated with cancer risk. They identify two variants with differential effects in bladder and breast cancer, and their in vitro results suggest that environmental exposures may induce tissue-specific APOBEC mutagenesis and contribute to oncogenesis in carriers of APOBEC3 risk variants.

    • Candace D Middlebrooks
    • A Rouf Banday
    • Ludmila Prokunina-Olsson
    Research
    Nature Genetics
    Volume: 48, P: 1330-1338

  • Whole-genome sequencing of matched serial tumours from patients identifies two key mutagenic factors (APOBEC3 and chemotherapy) and extrachromosomal DNA-forming structural variants that drive treatment resistance in urothelial cancer.

    • Duy D. Nguyen
    • William F. Hooper
    • Bishoy M. Faltas
    ResearchOpen Access
    Nature
    Volume: 635, P: 219-228