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Showing 1–15 of 15 results
Advanced filters: Author: A. Royant Clear advanced filters

  • The atomic resolution structure of a microbial sensory rhodopsin interacting with its cognate transducer protein casts light on signal transmission between two membrane proteins.

    • John Spudich
    News & Views
    Nature Structural Biology
    Volume: 9, P: 797-799

  • Cyan variants of green fluorescent protein (CFPs) are widely used as donors in FRET experiments. Here, a new CFP, mTurquoise2, is developed, which displays a high-fluorescence quantum yield and a long mono-exponential fluorescence lifetime.

    • Joachim Goedhart
    • David von Stetten
    • Antoine Royant
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-9

  • Here, the authors present four high-resolution structures of SyHR protein from cyanobacterial anion pumps family: chloride and sulfate bound forms and two active state structures. These structures provide insights into the molecular mechanisms of SyHR and cyanobacterial anion pumps in general.

    • R. Astashkin
    • K. Kovalev
    • V. Gordeliy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The bacterial thymidylate synthase ThyX catalyzes the reductive methylation of deoxyuridylate (dUMP) into deoxythymidylate (dTMP) and requires both folate and flavin for activity. Here, the authors combine biochemical experiments, spectroscopic measurements and flavin synthesis chemistry to show that formaldehyde (CH2O) can replace the natural methylene donor of ThyX in a CH2O-shunt reaction, yielding a carbinolamine intermediate with the reduced flavin coenzyme, and they present the crystal structure of this intermediate.

    • Charles Bou-Nader
    • Frederick W. Stull
    • Djemel Hamdane
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • The Na+-pumping KR2 rhodopsin from Krokinobacter eikastus is a light-driven non-proton cation pump whose mechanism of pumping remains to be understood. Here authors solved crystal structures of the O-intermediate state of the pentameric form of KR2 and its D116N and H30A mutants, which sheds light on the mechanism of non-proton cation light-driven pumping.

    • Kirill Kovalev
    • Roman Astashkin
    • Valentin Gordeliy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Infrared fluorescent proteins offer advantages for deep in vivo imaging thanks to the tissue-penetrating properties of infrared light. Here, Yu et al. design a monomeric infrared fluorescent protein that, when combined with expression of haeme oxygenase in cells, shows improved performance for in vivoimaging of neurons and brain tumours.

    • Dan Yu
    • William Clay Gustafson
    • Xiaokun Shu
    Research
    Nature Communications
    Volume: 5, P: 1-7

  • Time-resolved serial femtosecond crystallography is used to reveal the structural changes that stabilize the charge-separation steps of electron-transfer reactions in the photosynthetic reaction centre of Blastochloris viridis on a timescale of picoseconds.

    • Robert Dods
    • Petra Båth
    • Richard Neutze
    Research
    Nature
    Volume: 589, P: 310-314

  • Crystallographic snapshots illustrate the catalytic cycle and illuminate the mechanism by which the enzyme Pdx1 shuttles intermediates between lysine residues in its two active sites during the biosynthesis of pyridoxal 5′-phosphate.

    • Matthew J Rodrigues
    • Volker Windeisen
    • Ivo Tews
    Research
    Nature Chemical Biology
    Volume: 13, P: 290-294

  • Two mScarlet variants with high brightness and fast maturation times have been evolved. These variants behave favorably as fusion tags and Förster resonance energy transfer acceptors.

    • Theodorus W. J. Gadella Jr.
    • Laura van Weeren
    • Antoine Royant
    Research
    Nature Methods
    Volume: 20, P: 541-545

  • Crystal structures of the microbial rhodopsin KR2, a recently discovered light-driven sodium pump, reveal the translocation pathway of sodium ions and shed light on the molecular mechanism of ion pumping.

    • Ivan Gushchin
    • Vitaly Shevchenko
    • Valentin Gordeliy
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 390-395

  • The streptococcal M1 protein can cause vascular leakage and tissue injury and these pathologies are dependent on its interaction with host fibrinogen and subsequent activation of neutrophils. This study presents the structural basis for this process.

    • Pauline Macheboeuf
    • Cosmo Buffalo
    • Partho Ghosh
    Research
    Nature
    Volume: 472, P: 64-68