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Showing 1–5 of 5 results
Advanced filters: Author: Aaron B. Bogutz Clear advanced filters

  • Although many species-specific imprinted genes have been identified, how the evolutionary switch from biallelic to imprinted expression occurs is still unknown. Here authors find that lineage-specific ERVs active as oocyte promoters can induce de novo DNA methylation at gDMRs and imprinting.

    • Aaron B. Bogutz
    • Julie Brind’Amour
    • Louis Lefebvre
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which induces transcriptional silencing of this allele in the early embryo.

    • Julien Richard Albert
    • Wan Kin Au Yeung
    • Matthew Lorincz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.

    • Julie Brind’Amour
    • Hisato Kobayashi
    • Matthew C. Lorincz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14