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Showing 1–4 of 4 results
Advanced filters: Author: Aaron F. Garretson Clear advanced filters

  • Dendritic cells play pivotal roles in the immune response to viral infection but are targeted by flaviviruses resulting in evasion of the host response. Here the authors show Zika but not Dengue virus limits the NF-κB response in monocyte derived dendritic cells diminishing their ability to activate T cells.

    • Ying-Ting Wang
    • Emilie Branche
    • Sujan Shresta
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Here, the authors discover small molecules that inhibit glycosylation processes that occur in the Golgi apparatus of cells. The molecules reversibly inhibit formation of elaborate glycan structures without affecting secretion of glycoproteins.

    • Daniel Madriz Sørensen
    • Christian Büll
    • Yoshiki Narimatsu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expression of inflammation- and metabolism-related genes to modulate DC functions.

    • Emilie Branche
    • Ying-Ting Wang
    • Aaron F. Carlin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15