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Showing 1–8 of 8 results
Advanced filters: Author: Aaron M. Hosios Clear advanced filters

  • Hosios et al. demonstrate that inhibition of mechanistic target of rapamycin complex 1 in cells and in tumors in mice leads to a lysosome-dependent but autophagy-independent shift in membrane lipid metabolism, resulting in increased intracellular triglyceride pools.

    • Aaron M. Hosios
    • Meghan E. Wilkinson
    • Brendan D. Manning
    Research
    Nature Metabolism
    Volume: 4, P: 1792-1811

  • Glycolysis is elevated in many cancers. In this study, the authors show that lactoylglutathione, a by-product of methylglyoxal produced from increased glycolysis, is elevated in lung cancer in mouse models and humans, arguing reactive metabolite production can be a liability for cancers.

    • Alba Luengo
    • Keene L. Abbott
    • Matthew G. Vander Heiden
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

    • Aaron M. Hosios
    • Brendan D. Manning
    News & Views
    Nature Cell Biology
    Volume: 20, P: 996-997

  • Garcia-Bermudez et al. and Sullivan et al. show that endogenous aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours, and that metformin depletes aspartate to limit tumour growth.

    • Lucas B. Sullivan
    • Alba Luengo
    • Matthew G. Vander Heiden
    Research
    Nature Cell Biology
    Volume: 20, P: 782-788

  • Here, the authors identify a previously unknown regulatory strategy used by Escherichia coli to control end-product levels of the pyrimidine biosynthetic pathway: this involves feedback regulation of the near-terminal pathway enzyme UMP kinase, with accumulation of UMP prevented by its degradation to uridine through UmpH, a phosphatase with a previously unknown function.

    • Marshall Louis Reaves
    • Brian D. Young
    • Joshua D. Rabinowitz
    Research
    Nature
    Volume: 500, P: 237-241