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Showing 1–5 of 5 results
Advanced filters: Author: Aaron M. Joffe Clear advanced filters

  • The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology. Here, the authors use a combination of live cell imaging and in vitro single molecule binding measurements to show that tandem calponin homology domains (CH1–CH2) are sensitive to actin filament conformation, biasing their subcellular localization.

    • Andrew R. Harris
    • Pamela Jreij
    • Daniel A. Fletcher
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Whole-exome sequencing (WES) has emerged as a transformative technology for biological discovery, but technical difficulties have so far prevented its widespread clinical use. Here, Eliezer Van Allen and colleagues are able to perform production-scale WES on small amounts of clinically acquired formalin-fixed, paraffin-embedded tumor tissues. Using a newly created WES clinical interpretation algorithm, they apply the complete clinical WES framework prospectively to patients and demonstrate how it can be used to directly affect patient care.

    • Eliezer M Van Allen
    • Nikhil Wagle
    • Levi A Garraway
    Research
    Nature Medicine
    Volume: 20, P: 682-688

  • On 27 ̶ 29 July 2021, the National Institute of Allergy and Infectious Diseases (NIAID) hosted a virtual workshop on the topic of secondary vaccine effects to discuss existing evidence, potential immunological mechanisms and associated public health implications.

    • Aaron M. Joffe
    • Eun-Chung Park
    • Kimberly M. Thompson
    News & Views
    Nature Immunology
    Volume: 22, P: 1363-1366

  • This protocol describes an in vitro assay for studying how phagocytosis is affected by specific changes to the target surface. The targets are made by coating glass beads with supported lipid bilayers followed by coupling proteins and other ligands of interest.

    • Aaron M. Joffe
    • Matthew H. Bakalar
    • Daniel A. Fletcher
    Protocols
    Nature Protocols
    Volume: 15, P: 2230-2246