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Showing 1–8 of 8 results
Advanced filters: Author: Aaron Pitre Clear advanced filters

  • cAMP export by ABCC4 is critical for localized signaling. Here, the authors revealed that PKA activation drives ABCC4 to the plasma membrane and organizes a PDZ-dependent protein network with actin cytoskeleton and scaffolds, like SCRIB, that stabilize the transporter and optimize cAMP efflux. Furthermore, the authors show that the potent ABCC4 inhibitor Ceefourin 2 disrupts this network, revealing a non-canonical mechanism of ABCC4 inhibition.

    • Jingwen Zhu
    • Sabina Ranjit
    • John D. Schuetz
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • p14ARF drives NPM1 phase separation and forms meso-scale assemblies that limit NPM1 dynamics. Here the authors show that p14ARF hydrophobic residues enhance NPM1 phase separation, promote p14ARF nucleolar partitioning, nucleolar NPM1 immobilization, and reduce cell viability.

    • Eric Gibbs
    • Qi Miao
    • Richard Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.

    • Aaron Pitre
    • Yubin Ge
    • John D. Schuetz
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The mechanisms underlying perinatal mortality due to intrahepatic cholestasis of pregnancy are not fully understood. Here, the authors show that absence of the nuclear receptor and bile acid regulator Nrli2 and the biliary transporter Abcb11 strongly reduces maternal serum bile acid levels, improving neonatal survival.

    • Yuanyuan Zhang
    • Fei Li
    • John D. Schuetz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Here, the authors use small angle neutron scattering and coarse-grained molecular dynamics simulations to demonstrate that condensates based on the granular components of nucleoli are network fluids.

    • Furqan Dar
    • Samuel R. Cohen
    • Rohit V. Pappu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17