Nature Search

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Catherine A. O’Brien
Aaron Pollett
John E. Dick
Research19 Nov 2006
Nature

Volume: 445, P: 106-110
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition

Evelyne Lima-Fernandes
Alex Murison
Catherine A. O’Brien
ResearchOpen Access29 Mar 2019
Nature Communications

Volume: 10, P: 1-14
“I just wanted more”: Hereditary cancer syndromes patients’ perspectives on the utility of circulating tumour DNA testing for cancer screening

Ella Adi-Wauran
Marc Clausen
Yvonne Bombard
Research11 Oct 2023
European Journal of Human Genetics

Volume: 32, P: 176-181
Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

Michael A Ko
Carla O Rosario
Carol J Swallow
Research17 Jul 2005
Nature Genetics

Volume: 37, P: 883-888
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Adam Shlien, Peter Campbell, Uri Tabori and colleagues report genome and exome sequencing of biallelic mismatch repair deficiency cancer samples from 12 children, including 10 high-grade gliomas. The hypermutational signature of the malignant glioma samples was consistent with a driver role for observed mutations in DNA polymerases ɛ or δ.

Adam Shlien
Brittany B Campbell
Uri Tabori
Research02 Feb 2015
Nature Genetics

Volume: 47, P: 257-262
ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas

Ghassan Allo
Marcus Q Bernardini
Blaise A Clarke
Research26 Jul 2013
Modern Pathology

Volume: 27, P: 255-261
Correlation of p53 Mutations in ThinPrep-Processed Fine Needle Breast Aspirates with Surgically Resected Breast Cancers

Aaron Pollett
Yvan C Bédard
Rita Kandel
Research01 Nov 2000
Modern Pathology

Volume: 13, P: 1173-1179
A novel complex mutation in MSH2 contributes to both Muir-Torre and Lynch Syndrome

Sheron Perera
Lily Ramyar
Bharati Bapat
Research13 Nov 2009
Journal of Human Genetics

Volume: 55, P: 37-41
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity

Kazazian and colleagues identify FAM46C/TENT5C as an interactor and negative regulator of PLK4 activity in centriole duplication. The authors also find that FAM46C expression strongly reduces cancer cell invasion, uncovering a role for FAM46C as tumor suppressor.

Karineh Kazazian
Yosr Haffani
Carol Jane Swallow
ResearchOpen Access17 Aug 2020
Communications Biology

Volume: 3, P: 1-14

Search

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

“I just wanted more”: Hereditary cancer syndromes patients’ perspectives on the utility of circulating tumour DNA testing for cancer screening

Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas

Correlation of p53 Mutations in ThinPrep-Processed Fine Needle Breast Aspirates with Surgically Resected Breast Cancers

A novel complex mutation in MSH2 contributes to both Muir-Torre and Lynch Syndrome

FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity

Search

Quick links

Search

Filter By:

Search

Quick links