Nature Search

Community assessment of methods to deconvolve cellular composition from bulk gene expression

Deconvolution methods infer levels of immune infiltration from bulk expression of tumour samples. Here, authors assess 6 published and 22 community-contributed methods via a DREAM Challenge using in vitro and in silico transcriptional profiles of admixed cancer and healthy immune cells.

Brian S. White
Aurélien de Reyniès
Andrew J. Gentles
ResearchOpen Access27 Aug 2024
Nature Communications

Volume: 15, P: 1-22
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Nona Sotoodehnia and colleagues report a meta-analysis of 14 genome-wide association studies for QRS interval, an electrocardiogram measurement of cardiac ventricular conduction. They identify 22 loci associated with QRS duration.

Nona Sotoodehnia
Aaron Isaacs
Dan E Arking
Research14 Nov 2010
Nature Genetics

Volume: 42, P: 1068-1076
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of energy balance.

Elizabeth K Speliotes
Cristen J Willer
Ruth J F Loos
Research10 Oct 2010
Nature Genetics

Volume: 42, P: 937-948
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies including 17,510 females from eight different population-based cohorts.

John R B Perry
Lisette Stolk
Joanne M Murabito
Research17 May 2009
Nature Genetics

Volume: 41, P: 648-650
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Kathryn Lunetta and colleagues report a meta-analysis of 22 genome-wide association studies for age at menopause. They identify 13 loci newly associated with age at natural menopause, including several candidate genes with roles in DNA repair and immune function.

Lisette Stolk
John R B Perry
Kathryn L Lunetta
Research22 Jan 2012
Nature Genetics

Volume: 44, P: 260-268
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associated with BMI.

Cathy E Elks
John R B Perry
Anna Murray
Research21 Nov 2010
Nature Genetics

Volume: 42, P: 1077-1085
New gene functions in megakaryopoiesis and platelet formation

A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.

Christian Gieger
Aparna Radhakrishnan
Nicole Soranzo
Research30 Nov 2011
Nature

Volume: 480, P: 201-208
Weight change over 9 years and subsequent risk of venous thromboembolism in the ARIC cohort

Simone A. French
Pamela L. Lutsey
Aaron R. Folsom
Research18 Sept 2020
International Journal of Obesity

Volume: 44, P: 2465-2471
Cerebral small vessel disease genomics and its implications across the lifespan

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

Muralidharan Sargurupremraj
Hideaki Suzuki
Stéphanie Debette
ResearchOpen Access08 Dec 2020
Nature Communications

Volume: 11, P: 1-18
Merging and emerging cohorts: Not worth the wait

How best to study the effects of genes and environment on US health? In the first of two commentaries, Walter C. Willett and his co-authors argue that investing in existing studies is the most efficient approach.

Walter C. Willett
William J. Blot
Meir J. Stampfer
Comments & Opinion18 Jan 2007
Nature

Volume: 445, P: 257-258
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert and colleagues report a meta-analysis of 14 genome-wide association studies of coronary disease (CAD) followed by replication in additional cohorts. They confirm 10 previously associated loci and identify 13 loci newly associated with CAD.

Heribert Schunkert
Inke R König
Nilesh J Samani
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 333-338
ABC transporter genes ABC-C6 and ABC-G33 alter plant-microbe-parasite interactions in the rhizosphere

Deborah Elizabeth Cox
Steven Dyer
Johnathan J. Dalzell
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

Exome sequence analysis of nearly 10,000 people was carried out to identify alleles associated with early-onset myocardial infarction; mutations in low-density lipoprotein receptor (LDLR) or apolipoprotein A-V (APOA5) were associated with disease risk, identifying the key roles of low-density lipoprotein cholesterol and metabolism of triglyceride-rich lipoproteins.

Ron Do
Nathan O. Stitziel
Sekar Kathiresan
Research10 Dec 2014
Nature

Volume: 518, P: 102-106
Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study

Duanping Liao
Gerardo Heiss
Veikko Salomaa
Research10 Nov 2004
Journal of Exposure Science & Environmental Epidemiology

Volume: 15, P: 319-328
Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

Santiago Rodriguez
Tom R Gaunt
Ian NM Day
ResearchOpen Access29 Apr 2015
European Journal of Human Genetics

Volume: 24, P: 106-112
Erratum: Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Janine van Loon
Abbas Dehghan
Christopher O'Donnell
Amendments and Corrections16 Jun 2016
European Journal of Human Genetics

Volume: 24, P: 1096
Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Janine van Loon
Abbas Dehghan
Christopher O'Donnell
Research21 Oct 2015
European Journal of Human Genetics

Volume: 24, P: 1035-1040

Search

Community assessment of methods to deconvolve cellular composition from bulk gene expression

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

New gene functions in megakaryopoiesis and platelet formation

Weight change over 9 years and subsequent risk of venous thromboembolism in the ARIC cohort

Cerebral small vessel disease genomics and its implications across the lifespan

Merging and emerging cohorts: Not worth the wait

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

ABC transporter genes ABC-C6 and ABC-G33 alter plant-microbe-parasite interactions in the rhizosphere

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study

Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

Erratum: Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Genome-wide association studies identify genetic loci for low von Willebrand factor levels

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