Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Aaron R. Robart Clear advanced filters

  • Group II introns, which are self-splicing catalytic RNAs, catalyze splicing in two distinct steps. The crystal structure of a group II intron in the pre-catalytic state directly preceding the first splicing step reveals a sharp kink in the backbone that presents the scissile phosphate of the splice site to the active site.

    • Russell T Chan
    • Aaron R Robart
    • Navtej Toor
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 555-557

  • RNA-cleaving DNAzymes exhibit potential as biosensors and in vivo knockdown agents, however, the structures of DNAzymes remain underexplored. Here, the authors report the 2.7 Å X-Ray crystal structure of a 10-23 DNAzyme–substrate complex in a homodimer conformation.

    • Evan R. Cramer
    • Sarah A. Starcovic
    • Aaron R. Robart
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-6

  • Group II introns are large, self-splicing RNAs that catalyze their own excision from pre-mRNA molecules. Here the authors determine the 3.7 Å crystal structure of the group II intron in the stage immediately before the second step of splicing and present a complete model for the second step of group II intron splicing.

    • Russell T. Chan
    • Jessica K. Peters
    • Navtej Toor
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • This study determines the structure of a branched lariat RNA, providing insights into rearrangement of the intron between the two steps of RNA splicing.

    • Aaron R. Robart
    • Russell T. Chan
    • Navtej Toor
    Research
    Nature
    Volume: 514, P: 193-197

  • MitoNEET is an iron-sulfur protein found in the outer mitochondrial membrane and implicated in several metabolic disorders. Here the crystal structure of mitoNEET with a bound sulfonamide ligand is reported and used to design new mitoNEET ligands.

    • Werner J. Geldenhuys
    • Timothy E. Long
    • Aaron R. Robart
    ResearchOpen Access
    Communications Chemistry
    Volume: 2, P: 1-9