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Showing 1–4 of 4 results
Advanced filters: Author: Aartik Sarma Clear advanced filters

  • Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

    • Lucile P. A. Neyton
    • Ravi K. Patel
    • Gabriela K. Fragiadakis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.

    • Aartik Sarma
    • Stephanie A. Christenson
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10