Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Abdellah Allali-Hassani Clear advanced filters

  • Discovery of a chemical probe targeting the PWWP domain of NSD2 reveals insight into mechanisms that govern NSD2 localization. The compound and its negative control represent valuable tools for further defining NSD2 biology.

    • David Dilworth
    • Ronan P. Hanley
    • Matthieu Schapira
    Research
    Nature Chemical Biology
    Volume: 18, P: 56-63

  • PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PRDM9 in biochemical and cellular assays

    • Abdellah Allali-Hassani
    • Magdalena M. Szewczyk
    • Masoud Vedadi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • A chemical probe BI-9321 for the PWWP1 domain of NSD3 and its inactive analog were identified. BI-9321 binds to the methyl-lysine binding site, reduces the association of NSD3 with chromatin and inhibits proliferation of acute myeloid leukemia cells.

    • Jark Böttcher
    • David Dilworth
    • Darryl B. McConnell
    Research
    Nature Chemical Biology
    Volume: 15, P: 822-829

  • A family of calcium-dependent protein kinases (CDPK), containing a calcium-binding domain, is present in apicomplexan parasites, ciliates and plants, but not in animals. Now crystal structures of CDPKs from Toxoplasma gondii and Cryptosporidium parvum in their apo or calcium-bound states reveal the structural reorganization induced by calcium that results in activation.

    • Amy K Wernimont
    • Jennifer D Artz
    • Raymond Hui
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 596-601

  • Protein lysine methyltransferases modulate the activities of chromatin and non-chromatin proteins by specific methylation of lysine side chains. A large-scale structure-based design approach has yielded a new chemical probe that potently and selectively inhibits G9a and GLP methyltransferases in cells.

    • Masoud Vedadi
    • Dalia Barsyte-Lovejoy
    • Jian Jin
    Research
    Nature Chemical Biology
    Volume: 7, P: 566-574