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Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer

Here, the authors characterize the epigenetic status of hybrid ecDNA in HPVOPC, identifying HPV oncogenes E6/E7 in hybrid ecDNA are flanked by somatic DNA enhancers with strong cis-interaction. It can be targeted with ecDNA disrupting therapeutics.

Takuya Nakagawa
Jens Luebeck
Joseph A. Califano
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-13

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Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer

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