Gadolinium-based contrast agents are the gold standard for magnetic resonance imaging (MRI), however, their poor stability causes safety problems in clinical applications. Here, the authors develop two chiral Gd(III) DOTA-based complexes with a macrocyclic backbone that show higher relaxivities and stabilities than benchmark complexes.
- Junhui Zhang
- Lixiong Dai
- Ga-Lai Law
