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Showing 1–2 of 2 results
Advanced filters: Author: Abhisek Mondal Clear advanced filters

  • Gabapentinoid drugs are widely used for pain, epilepsy and mental disorders. Chen et al. report the structure of a gabapentin-bound brain and heart calcium channel, revealing the gabapentin binding site and isoform-selective binding determinants.

    • Zhou Chen
    • Abhisek Mondal
    • Daniel L. Minor Jr
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 735-739

  • Interactions between the endoplasmic reticulum membrane protein complex (EMC) and the high-voltage-activated calcium channel CaVα2δ are mutually exclusive, and EMC-to-CaVα2δ hand-off involves a divalent ion-dependent step and CaV1.2 element ordering.

    • Zhou Chen
    • Abhisek Mondal
    • Daniel L. Minor Jr
    Research
    Nature
    Volume: 619, P: 410-419