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Showing 1–5 of 5 results
Advanced filters: Author: Acely Garza-Garcia Clear advanced filters

  • TRIM E3 ligases are key regulators of numerous cellular functions, yet their mechanism of action remains poorly understood. Here, the authors show that paralogous TRIM2 and TRIM3 adopt different self-association and activity profiles but interact in cells to modulate their respective activities.

    • Diego Esposito
    • Jane Dudley-Fraser
    • Katrin Rittinger
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Active and inactive state ATP-phosphoribosyltransferases (ATP-PRTs) are believed to have different conformations. Here the authors show that in both states, ATP-PRT has a similar structural arrangement, suggesting that dynamic alterations are involved in ATP-PRT regulation by allosteric modulators.

    • João P. Pisco
    • Cesira de Chiara
    • Luiz Pedro S. de Carvalho
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Changes in glycoprotein expression are correlates of disease, but secreted glycoproteins cannot be accurately traced to their cell line of origin. Here, the authors develop a strategy to chemically tag and profile glycoproteins in a cell line-specific manner in co-culture systems and in vivo.

    • Anna Cioce
    • Beatriz Calle
    • Benjamin Schumann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • d-Cycloserine inactivates alanine racemase by forming an adduct with the pyridoxal 5′-phosphate cofactor, but structural and spectroscopic analyses reveal that reactivation occurs on adduct hydrolysis and product rearrangement to a stable oxime.

    • Cesira de Chiara
    • Miha Homšak
    • Luiz Pedro S. de Carvalho
    Research
    Nature Chemical Biology
    Volume: 16, P: 686-694