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Showing 1–4 of 4 results

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Mosaic vaccines elicit CD8⁺ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys

Vaccine design is challenging when the infectious agent is genetically diverse. Polyvalent 'mosaic' antigens might be used to address this challenge, and these two studies show promising results in monkeys infected with HIV-1 (pages 268–270 and pages 319–323).

Sampa Santra
Hua-Xin Liao
Norman L Letvin
Research21 Feb 2010
Nature Medicine

Volume: 16, P: 324-328
Virtual terminator nucleotides for next-generation DNA sequencing

Nucleotide analogs modified with a free 3′ hydroxyl, maintaining the interactions at the polymerase active site, and a cleavable linker, attaching a fluorescent dye and an inhibitor, are efficient at reading homopolymer runs in a single-molecule sequencing reaction.

Jayson Bowers
Judith Mitchell
John F Thompson
Research20 Jul 2009
Nature Methods

Volume: 6, P: 593-595
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV

The analysis of multiple SIV vaccine regimens in macaques leads to the identification of a key two-amino-acid signature that confers resistance to neutralizing antibodies; a similar mechanism of immune escape is shown to operate in HIV and may explain the limited efficacy seen in HIV vaccine trials.

Mario Roederer
Brandon F. Keele
John R. Mascola
Research18 Dec 2013
Nature

Volume: 505, P: 502-508
A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Monir Ejemel
Todd G. Smith
Yang Wang
ResearchOpen Access07 Jun 2022
Scientific Reports

Volume: 12, P: 1-11