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Showing 1–12 of 12 results
Advanced filters: Author: Adam Godzik Clear advanced filters

  • The 501Y.V2 variant of SARS-CoV-2 in South Africa became dominant over other variants within weeks of its emergence, suggesting that this variant is linked to increased transmissibility or immune escape.

    • Houriiyah Tegally
    • Eduan Wilkinson
    • Tulio de Oliveira
    Research
    Nature
    Volume: 592, P: 438-443

  • SARS-CoV-2 genomic surveillance has been important for informing pandemic responses but many regions remain under-sampled, limiting knowledge of circulating strains. Here, the authors sequence 378 isolates from Nigeria and identify two strains that appear to be important locally though globally uncommon.

    • Egon A. Ozer
    • Lacy M. Simons
    • Ramon Lorenzo-Redondo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.

    • Anderson F. Brito
    • Elizaveta Semenova
    • Nuno R. Faria
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Analysis of primary protein sequences and tertiary structures has yielded important insights into the evolution of protein function, but little is known about the evolution of functional mechanisms and protein dynamics. An integrated approach including structural biology, mutagenesis, bioinformatics analyses and cell biology has now uncovered evolutionary aspects of the motions present in the dihydrofolate reductase enzyme family.

    • Gira Bhabha
    • Damian C Ekiert
    • Peter E Wright
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1243-1249

  • Cross-neutralization assays of early variants and the 501Y.V2 variant of SARS-CoV-2 show that plasma from individuals infected with 501Y.V2 effectively neutralizes all variants, indicating that a vaccine that targets 501Y.V2 may also be effective against other SARS-CoV-2 variants.

    • Sandile Cele
    • Inbal Gazy
    • Alex Sigal
    Research
    Nature
    Volume: 593, P: 142-146

  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
    Reviews
    Nature
    Volume: 605, P: 640-652

  • Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

    • Michael P. Menden
    • Dennis Wang
    • Julio Saez-Rodriguez
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17