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Showing 1–10 of 10 results
Advanced filters: Author: Adam Handel Clear advanced filters

  • Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TEC subset, and hampers T cell development.

    • Thomas Barthlott
    • Adam E. Handel
    • Georg A. Holländer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Although the importance of thymic epithelial cells (TEC) in thymus physiology is established, the development of functionally diverse TEC populations remains incompletely understood. Here, using fate-mapping experiments in the embryonic thymus, the authors identify keratin19+ multipotent progenitor cells that support medullary TEC diversity in adulthood.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • T cell development requires functionally diverse thymic epithelial cell (TEC) populations performing specific functions. Here, using massively parallel flow cytometry and machine learning, the authors examine in mice the TEC compartment from the perinatal period to adulthood, identify novel phenotypic markers and characterize the function of perinatal cortical TEC.

    • Fabian Klein
    • Clara Veiga-Villauriz
    • Georg A. Holländer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Gene-expression studies are used to elucidate the relationship between cholesterol regulation and angiogenesis: apolipoprotein A-1 binding protein (AIBP) is found to enhance cholesterol influx from endothelial cells to high-density lipoprotein, and the resulting cholesterol depletion alters membrane lipid order in the vasculature, leading to decreased vascular endothelial growth factor receptor signalling.

    • Longhou Fang
    • Soo-Ho Choi
    • Yury I. Miller
    Research
    Nature
    Volume: 498, P: 118-122

  • In this Review, Handel and colleagues examine the contribution of thymic T cell selection to CNS autoimmune conditions and consider how a better understanding of this contribution could lead to novel therapeutic strategies for these conditions.

    • Adam E. Handel
    • Sarosh R. Irani
    • Georg A. Holländer
    Reviews
    Nature Reviews Neurology
    Volume: 14, P: 723-734

  • Epidemiological data indicate that genetic and environmental factors interact to determine an individual's risk of developing multiple sclerosis (MS). Handel et al. examine the key periods of life during which the environment might contribute to MS susceptibility, focusing on three putative MS risk factors: sun exposure (and its relationship with vitamin D levels), Epstein–Barr virus infection, and smoking.

    • Adam E. Handel
    • Gavin Giovannoni
    • Sreeram V. Ramagopalan
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 156-166

  • Multiple sclerosis and type 1 diabetes mellitus are seemingly very different autoimmune diseases. However, this Review discusses recent studies in genetics, epidemiology and immunology that have uncovered many features common to both disorders. Overlaps between T1DM and MS might lead to similar strategies in preventing and treating these debilitating conditions.

    • Adam E. Handel
    • Lahiru Handunnetthi
    • Sreeram V. Ramagopalan
    Reviews
    Nature Reviews Endocrinology
    Volume: 5, P: 655-664

  • Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.

    • Bergithe E. Oftedal
    • Stefano Maio
    • Georg A. Holländer
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14