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Showing 1–17 of 17 results
Advanced filters: Author: Adam J. Engler Clear advanced filters

  • The researchers exploit exciton-to-trion conversion in ångström-thick semiconductors for all-optical detection of electrical activity in cardiomyocyte cultures. This approach affords high temporal resolution and paves the way for elusive label-free all-optical voltage-sensing applications of two-dimensional semiconductor materials in the biological domain.

    • Yundong Ren
    • Chawina De-Eknamkul
    • Ertugrul Cubukcu
    Research
    Nature Photonics
    Volume: 19, P: 540-548

  • Small cell lung cancers (SCLC) have often inactivating mutations in RB1. In this study, the authors demonstrate that RB1 loss mediates low expression of YAP1 in SCLC tumors ultimately promoting metastasis and they propose to use benzamide family HDAC inhibitors to induce YAP1 expression for prevention of metastases.

    • Zhengming Wu
    • Junhui Su
    • Kun-Liang Guan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Genome-edited human pluripotent stem cells and genome-edited mouse models reveal that combinatorial genetic interactions contribute to the complex genetic heritability of human cardiomyopathy.

    • Dekker C. Deacon
    • Cassandra L. Happe
    • Neil C. Chi
    Research
    Nature Biomedical Engineering
    Volume: 3, P: 147-157

  • Single-cell RNA sequencing was used to construct a map of gene expression in lesions from brains of patients with multiple sclerosis, revealing distinct lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation.

    • Lucas Schirmer
    • Dmitry Velmeshev
    • David H. Rowitch
    Research
    Nature
    Volume: 573, P: 75-82

  • Experiments have shown that the physical characteristics of the matrix surrounding a stem cell can affect its behaviour. This picture gets further complicated by studies of stem cells and their differentiated counterparts that show that the cells' own softness also has a clear role in how they respond to stress.

    • Andrew W. Holle
    • Adam J. Engler
    News & Views
    Nature Materials
    Volume: 9, P: 4-6

  • Recent work has proposed that both protein tethering to the extracellular matrix and matrix porosity can regulate stem cell differentiation. It is now shown that differentiation is driven by matrix stiffness independently of tethering and porosity.

    • Jessica H. Wen
    • Ludovic G. Vincent
    • Adam J. Engler
    Research
    Nature Materials
    Volume: 13, P: 979-987

  • The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ.

    • Zhipeng Meng
    • Yunjiang Qiu
    • Kun-Liang Guan
    Research
    Nature
    Volume: 560, P: 655-660

  • Stem cells alter their morphology and differentiate to particular lineages in response to biophysical cues from the surrounding matrix. When the matrix is degradable, however, cell fate is morphology-independent and is directed by the traction forces that the cells actively apply after they have degraded the matrix.

    • Ludovic G. Vincent
    • Adam J. Engler
    News & Views
    Nature Materials
    Volume: 12, P: 384-386

  • This Review discusses how biomaterials can be used to recreate and understand the influence of specific tumour microenvironment properties on cancer progression and highlights materials-based strategies to capture, detect and assess metastatic cancer cells in vitro and in vivo.

    • Pranjali Beri
    • Bibiana F. Matte
    • Adam J. Engler
    Reviews
    Nature Reviews Materials
    Volume: 3, P: 418-430

  • Inherent properties of materials, such as their adhesiveness to cells, nanotopography, stiffness, degradability or chemical functionality, can influence the fate of stem cells. This Review discusses recent evidence of how inherent material properties can be engineered to regulate stem cell decisions, as well as of signal-transduction mechanisms that convert material stimuli into biochemical signals.

    • William L. Murphy
    • Todd C. McDevitt
    • Adam J. Engler
    Reviews
    Nature Materials
    Volume: 13, P: 547-557