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Showing 1–6 of 6 results
Advanced filters: Author: Adam J. Riesselman Clear advanced filters

  • The ability to design functional sequences is central to protein engineering and biotherapeutics. Here the authors introduce a deep generative alignment-free model for sequence design applied to highly variable regions and design and test a diverse nanobody library with improved properties for selection experiments.

    • Jung-Eun Shin
    • Adam J. Riesselman
    • Debora S. Marks
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The East Antarctic ice sheet is considered to be largely insensitive to temperature changes in the Southern Ocean. Marine sediment records indicate the East Antarctic ice sheet repeatedly retreated by several hundred kilometres during intervals of Pliocene warmth.

    • Carys P. Cook
    • Tina van de Flierdt
    • Masako Yamane
    Research
    Nature Geoscience
    Volume: 6, P: 765-769

  • The growth of ice on Antarctica about 34 million years ago affected sea level. A combination of modelling and marine sediment analyses shows that sea level near the developing ice sheet first fell and then rose as a result of crustal deformation imposed by the ice growth.

    • Paolo Stocchi
    • Carlota Escutia
    • Masako Yamane
    Research
    Nature Geoscience
    Volume: 6, P: 380-384

  • A major challenge in protein design is to augment existing functional proteins with multiple property enhancements. Here the authors use the evolutionary model EVcouplings to computationally design highly mutated variants of TEM-1 ß-lactamase, and characterise these designs experimentally.

    • Benjamin Fram
    • Yang Su
    • Nicholas P. Gauthier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16