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Showing 1–4 of 4 results
Advanced filters: Author: Adam Lerer Clear advanced filters

  • SIMBA learns a co-embedding space of single cells and multiple features such as genes, chromatin-accessible regions and transcription-factor-binding sequences, boosting the performances of various analyses of cellular diversity and regulation.

    • Huidong Chen
    • Jayoung Ryu
    • Luca Pinello
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1003-1013

  • A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

    • Vassily Trubetskoy
    • Antonio F. Pardiñas
    • Jim van Os
    Research
    Nature
    Volume: 604, P: 502-508

  • The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

    • Christian R Marshall
    • Daniel P Howrigan
    • Jonathan Sebat
    Research
    Nature Genetics
    Volume: 49, P: 27-35