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Showing 1–4 of 4 results
Advanced filters: Author: Adam M. Damry Clear advanced filters

  • The development of a computational protein design method, meta-multistate design, enables the design and validation of protein variants termed DANCERs that spontaneously exchange between predicted conformational states on the millisecond timescale.

    • James A Davey
    • Adam M Damry
    • Roberto A Chica
    Research
    Nature Chemical Biology
    Volume: 13, P: 1280-1285

  • The ability to rationally remodel enzyme conformational landscapes to modify catalytic properties is limited. Here, the authors, using a computational procedure, redesign the conformational landscape of an aminotransferase to stabilize a less populated but reactive conformation and thereby increase catalytic efficiency with a non-native substrate.

    • Antony D. St-Jacques
    • Joshua M. Rodriguez
    • Roberto A. Chica
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Damry et al. evaluates the impact of individual substitutions in primary sequence of a globular protein on its conformational dynamics. They demonstrate that only two mutations in core residues of a streptococcal protein (Gβ1) variant can synergistically create conformational exchange, one destabilizing the native structure while the other allowing two new conformational states to be accessed on the energy landscape.

    • Adam M. Damry
    • Marc M. Mayer
    • Roberto A. Chica
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10

  • Previous work identified goddard as a putative de novo evolved gene in Drosophila melanogaster. Here, the authors characterize the structure and function of the Goddard protein in D. melanogaster, and they infer its ancestral and extant structures across the Drosophila genus.

    • Andreas Lange
    • Prajal H. Patel
    • Erich Bornberg-Bauer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13