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Showing 1–11 of 11 results
Advanced filters: Author: Adam Perriman Clear advanced filters

  • Freeze-drying of aqueous myoglobin–polymer surfactant nanoconjugates affords a water-free solid that melts at room temperature to produce a viscous solventless liquid protein that exhibits near-native secondary structure and reversible dioxygen binding. The results challenge the accepted role of solvent molecules in mediating protein structure and function, and offer new opportunities in protein-based nanoscience and bionanotechnology.

    • Adam W. Perriman
    • Alex P. S. Brogan
    • Stephen Mann
    Research
    Nature Chemistry
    Volume: 2, P: 622-626

  • Membrane-enclosed reaction compartments are considered important for establishing plausible pathways of prebiotic organization. Here, simple mixing of mononucleotides and cationic peptides in water is shown to produce microdroplets that sequester photo-active molecules, catalytic nanoparticles and enzymes. Such droplets might provide plausible pathways of prebiotic organization prior to the emergence of membrane-based compartmentalization on the early Earth.

    • Shogo Koga
    • David S. Williams
    • Stephen Mann
    Research
    Nature Chemistry
    Volume: 3, P: 720-724

  • Avoiding central cell necrosis at the centre of large engineered tissue constructs is an important issue forin vitrotissue engineering. Here, the authors demonstrate that this problem may be overcome by oxygenating human mesenchymal stem cells with artificial membrane-binding proteins.

    • James P. K. Armstrong
    • Rameen Shakur
    • Anthony P. Hollander
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-6

  • The incorporation of cells into tissue engineering scaffolds can be a major challenge. Here, the authors report on anchoring thrombin to cell membranes for the in situ formation of fibrin scaffolds around the modified cells, demonstrate scaffold formation in vitro and show cell survival in vivo.

    • Robert C. Deller
    • Thomas Richardson
    • Adam W. Perriman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Enzymatic reactions typically occur in aqueous media or with hydrated enzymes. Here, the authors form fluid enzyme-polymer conjugates with sub-solvation levels of water, and demonstrate catalytic hydrolysis in the absence of a solvent at high temperatures.

    • Alex P. S. Brogan
    • Kamendra P. Sharma
    • Stephen Mann
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • A hybrid protocell model is described in which a fatty acid membrane spontaneously assembles on the surface of coacervate microdroplets with molecularly crowded interiors. The membrane-enclosed protocells exhibit uptake and exclusion properties that differ from the uncoated droplets. The internal structure can be disassembled at high ionic strength without loss of membrane integrity. This model may help to reconcile alternative mechanisms of prebiotic compartmentalization.

    • T-Y. Dora Tang
    • C. Rohaida Che Hak
    • Stephen Mann
    Research
    Nature Chemistry
    Volume: 6, P: 527-533

  • Biointerfacing techniques face challenges in stiffness matching at interfaces between hard and soft tissues, crucial for advanced biomechanical applications. Here, a 3D printable, biocompatible composite is developed that achieves a wide range of elastic moduli from 15 kPa to 1.4 GPa.

    • Mohammad Naghavi Zadeh
    • Kapil D. Patel
    • Jonathan Rossiter
    ResearchOpen Access
    Communications Materials
    Volume: 6, P: 1-14

  • Hydrogels are useful structural materials due to their viscoelasticity, which provides supportive and dissipative properties. Here, a dialysis–casting method was used to fabricate alginate hydrogels, using poloxamer 407 as a porogen, with tunable porosity topologies and high damping properties.

    • Graham J. Day
    • Qicheng Zhang
    • Fabrizio Scarpa
    ResearchOpen Access
    Communications Materials
    Volume: 6, P: 1-10