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Nature Genetics (1)

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H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs

Restricting or permitting H3K27me3 spreading concentrates or dilutes canonical PRC1 (cPRC1), respectively, which affects three-dimensional chromatin interactions. Disruption of cPRC1 compromises repression of Polycomb target genes and induces differentiation and tumor regression in H3K27M-mutant glioma.

Brian Krug
Bo Hu
Chao Lu
Research18 May 2026
Nature Genetics

P: 1-15

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H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs

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