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Showing 1–5 of 5 results
Advanced filters: Author: Adam Redzej Clear advanced filters

  • Cryo-electron microscopy structures of a 2.8 megadalton bacterial type IV secretion system encoded by the plasmid R388 and comprising 92 polypeptides provide insights into the stepwise mechanism of pilus assembly.

    • Kévin Macé
    • Abhinav K. Vadakkepat
    • Gabriel Waksman
    ResearchOpen Access
    Nature
    Volume: 607, P: 191-196

  • The bacterial stressosome is a large nanomachine and a key inducer of stress response. Here, the authors present the cryo-EM structure of the stressosome from the bacterial pathogen Listeria monocytogenes at 3.38 Å resolution and discuss its activation mechanism.

    • Allison H. Williams
    • Adam Redzej
    • Pascale Cossart
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • In this Review, Waksman and colleagues describe the structural and mechanistic details of the six secretion systems (types I–VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone–usher pathway and the curli biogenesis machinery. They discuss both conserved and divergent properties of these systems and their potential as targets of novel antibacterial compounds.

    • Tiago R. D. Costa
    • Catarina Felisberto-Rodrigues
    • Gabriel Waksman
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 343-359

  • A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion mechanisms.

    • Amit Meir
    • Kevin Macé
    • Gabriel Waksman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The three-dimensional structure of the type IV secretion system encoded by the Escherichia coli R388 conjugative plasmid.

    • Harry H. Low
    • Francesca Gubellini
    • Gabriel Waksman
    Research
    Nature
    Volume: 508, P: 550-553