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Structure of phage P22 cell envelope–penetrating needle

Adam S Olia
Sherwood Casjens
Gino Cingolani
Research02 Dec 2007
Nature Structural & Molecular Biology

Volume: 14, P: 1221-1226
A broadly protective human antibody for GI genogroup noroviruses

At present, there are no countermeasures against the GI genogroup of noroviruses. The authors characterize a protective human antibody that broadly recognizes this genogroup.

Inga Rimkute
Adam S. Olia
Mario Roederer
Research10 Apr 2025
Nature Microbiology

Volume: 10, P: 1227-1239
Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B

Cryo-EM structures of the stabilized prefusion conformation of the glycoprotein B ectodomain—the HSV-1 entry machine—identify a prefusion-specific neutralizing antibody and reveal how prefusion glycoprotein B may evade antibody-mediated neutralization.

Ryan S. Roark
Andrew J. Schaub
Peter D. Kwong
ResearchOpen Access31 Oct 2025
Nature Microbiology

Volume: 10, P: 2966-2980
Publisher Correction: A non-human primate model for human norovirus infection

Inga Rimkute
Natthawan Chaimongkol
Mario Roederer
Amendments and Corrections15 Feb 2024
Nature Microbiology

Volume: 9, P: 877
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization

The third variable (V3) loop on the HIV-1 Env glycoprotein is required for viral entry. Here, the authors applied DARPin technology to produce broadly neutralizing inhibitors targeting a region of V3 that becomes accessible after binding to the CD4 receptor.

Matthias Glögl
Nikolas Friedrich
Alexandra Trkola
ResearchOpen Access21 Aug 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1323-1336
Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains

Here the authors isolate monoclonal antibody HmAb64 from a healthy volunteer who received an experimental polyvalent DNA prime-protein boost HIV vaccine, and show that it’s specific for the CD4 binding site and neutralizes cross-subtype HIV isolates including several tier-2 viruses.

Shixia Wang
Kun-Wei Chan
Shan Lu
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-13
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

Antibodies targeting the HIV-1 fusion peptide rarely achieve more than 60% neutralization breadth. Here, the authors develop an anti-FP antibody enhancing its potency to 80% and structurally resolve the expanded FP-binding site that allows the antibody to target diverse viral variants.

Bailey B. Banach
Sergei Pletnev
Brandon J. DeKosky
ResearchOpen Access21 Nov 2023
Nature Communications

Volume: 14, P: 1-17
A non-human primate model for human norovirus infection

Rhesus macaques are susceptible to oral challenge of human noroviruses and can be used as a model to recapitulate infection and adaptive immune responses in humans.

Inga Rimkute
Natthawan Chaimongkol
Mario Roederer
Research06 Feb 2024
Nature Microbiology

Volume: 9, P: 776-786
A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins

Homotrimeric DARPin molecules neutralize SARS-CoV-2 variants of concern by targeting a critical ACE2-binding interface.

Vikas Chonira
Young D. Kwon
Zhilei Chen
Research21 Nov 2022
Nature Chemical Biology

Volume: 19, P: 284-291
A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

A bulky residue in the stem domain of the influenza virus H2 hemagglutinin appears pivotal in eliciting broadly cross-reactive antibodies capable of recognizing diverse group 1 influenza subtypes and is informative for universal influenza vaccine development.

Sarah F. Andrews
Julie E. Raab
Adrian B. McDermott
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 373-382
Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

Here, the authors analyse the distance between the body of an antibody and a protein antigen denoted as the Antibody-Framework-to-Antigen Distance (AFAD) for about 2000 non-redundant antibody-protein antigen complexes in the Protein Data Bank. They observe that antibodies with exceptionally long AFADs were all broad HIV-1-neutralizing antibodies that targeted densely glycosylated regions on the HIV-1-envelope trimer. The connection between long AFAD and dense glycan was further validated by the cryo-EM structure of antibody 2909 recognizing a glycan hole and by glycan shielding analyses based on molecular dynamics simulations.

Myungjin Lee
Anita Changela
Peter D. Kwong
ResearchOpen Access09 Nov 2021
Nature Communications

Volume: 12, P: 1-10
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants

Multivalent nanobodies against SARS-CoV-2 from mice engineered to produce camelid nanobodies recognize conserved epitopes that are inaccessible to human antibodies and show promise as a strategy for dealing with viral escape mutations.

Jianliang Xu
Kai Xu
Rafael Casellas
ResearchOpen Access07 Jun 2021
Nature

Volume: 595, P: 278-282
Three-dimensional structure of a viral genome-delivery portal vertex

Bacteriophages deliver their genome into the host cell through large proteinaceous assemblies called portal proteins. The first high-resolution structure of a portal protein from the Podovirae family reveals a ~1.1-MDa assembly formed by 24 proteins and a second structure uncovers an unexpected barrel-shaped domain that is essential for infectivity.

Adam S Olia
Peter E Prevelige Jr
Gino Cingolani
Research17 Apr 2011
Nature Structural & Molecular Biology

Volume: 18, P: 597-603
Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells

Krisztina Percze
Zoltán János Tolnai
Tamás Mészáros
ResearchOpen Access09 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

Cuiping Liu
Lingshu Wang
John R. Mascola
ResearchOpen Access08 Aug 2023
npj Vaccines

Volume: 8, P: 1-10
A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

Baoshan Zhang
Cara W. Chao
Peter D. Kwong
ResearchOpen Access23 Oct 2020
Scientific Reports

Volume: 10, P: 1-13

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