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Showing 1–5 of 5 results
Advanced filters: Author: Adele M. Snowman Clear advanced filters
  • The gasotransmitter hydrogen sulfide signals by sulfide modification of target proteins. Vandiver and colleagues study the sulfhydration of parkin by hydrogen sulfide and find that sulfhydration stimulates its activity, and that this activity is reduced in patients with Parkinson’s disease.

    • M. Scott Vandiver
    • Bindu D. Paul
    • Solomon H. Snyder
    Research
    Nature Communications
    Volume: 4, P: 1-7
  • Cystathionine γ-lyase, which is responsible for the production of cysteine, is decreased in the striatum and cortex of mouse models of Huntington’s disease and in patients with Huntington’s disease, and cysteine supplementation in diet and drinking water partly rescues the phenotype and the diminished longevity of the mouse model.

    • Bindu D. Paul
    • Juan I. Sbodio
    • Solomon H. Snyder
    Research
    Nature
    Volume: 509, P: 96-100
  • H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.

    • Urbain Weyemi
    • Bindu D. Paul
    • Solomon H. Snyder
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10
  • The activity of myriad nuclear proteins is regulated by S-nitrosylation, but a nuclear nitrosylase has remained elusive. GAPDH is now shown to be nitrosylated in the cytoplasm, which promotes its import into the nucleus, where it then transnitrosylates nuclear proteins.

    • Michael D. Kornberg
    • Nilkantha Sen
    • Solomon H. Snyder
    Research
    Nature Cell Biology
    Volume: 12, P: 1094-1100