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Showing 1–4 of 4 results
Advanced filters: Author: Adeline Goulet Clear advanced filters

  • Phages can use ACR proteins that inhibit the adaptive immunity activities of bacterial CRISPR-Cas systems. Here, Philippe et al. show that these systems can block ACR-containing phages by targeting the acr gene, and this can select for phage mutants carrying a deletion within acr that does not block DNA cleavage (interference) but prevents the addition of new immunity (spacer acquisition).

    • Cécile Philippe
    • Carlee Morency
    • Sylvain Moineau
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.

    • Julie Salomon
    • Cécile Gaston
    • Delphine Delacour
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.

    • Alexander P. Hynes
    • Geneviève M. Rousseau
    • Sylvain Moineau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10