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Showing 1–3 of 3 results
Advanced filters: Author: Adi Alajem Clear advanced filters

  • There is increasing evidence that an 'open' chromatin state contributes to maintenance of pluripotency in stem cells, and that this requires regulation of both the global chromatin state and local repression of transcription. This regulation may also be relevant for chromatin control during reprogramming or during tumorigenesis.

    • Alexandre Gaspar-Maia
    • Adi Alajem
    • Miguel Ramalho-Santos
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 36-47

  • A hallmark of stem cells is an open chromatin largely devoid of heterochromatin, but which molecules are required to maintain it is unknown, as well as whether an open chromatin is necessary for the differentiation potential of stem cells. Here, the chromatin remodelling factor Chd1 is shown to be required to maintain the open chromatin state of pluripotent mouse embryonic stem cells and to be essential for the pluripotency of these cells.

    • Alexandre Gaspar-Maia
    • Adi Alajem
    • Miguel Ramalho-Santos
    Research
    Nature
    Volume: 460, P: 863-868