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Showing 1–4 of 4 results

Advanced filters: Author: Adi Steif Clear advanced filters

Scalable whole-genome single-cell library preparation without preamplification

Direct library preparation (DLP) is a robust and economic method for preparing large numbers of single-cell whole-genome sequencing libraries without preamplification, to study copy-number heterogeneity at the cell level and other variant types at the clone or population level.

Hans Zahn
Adi Steif
Carl L Hansen
Research09 Jan 2017
Nature Methods

Volume: 14, P: 167-173
A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast

Single-cell RNA sequencing analysis of over 800,000 human adult breast cells from 55 female donors identifies 41 cell subtypes and highlights age- and parity-dependent effects. Samples from healthy women with germline mutations in BRCA1 or BRCA2 showed signs of T cell exhaustion.

Austin D. Reed
Sara Pensa
Walid T. Khaled
ResearchOpen Access28 Mar 2024
Nature Genetics

Volume: 56, P: 652-662
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Deep-genome and single-cell sequencing analyses of patient-derived breast cancer xenografts reveal extensive, dynamic and reproducible changes in intra-tumoral mutational clonal composition on engraftment and serial propagation.

Peter Eirew
Adi Steif
Samuel Aparicio
Research26 Nov 2014
Nature

Volume: 518, P: 422-426
E-scape: interactive visualization of single-cell phylogenetics and cancer evolution

Maia A Smith
Cydney B Nielsen
Sohrab P Shah
Correspondence30 May 2017
Nature Methods

Volume: 14, P: 549-550