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Showing 1–5 of 5 results
Advanced filters: Author: Adina Hughes Clear advanced filters

  • The ATR inhibitor ceralasertib has shown clinical activity in combination with immune-checkpoint inhibitors in several cancer types. Here the authors report the anti-tumor activity and the immunomodulatory changes, dependent on up-regulation of type I interferon pathway, following intermittent ATR inhibition in preclinical cancer models.

    • Elizabeth L. Hardaker
    • Emilio Sanseviero
    • Simon T. Barry
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Genome-wide ancient DNA data from 225 individuals who lived in southeastern Europe between 12000 and 500 bc reveals that the region acted as a genetic crossroads before and after the arrival of farming.

    • Iain Mathieson
    • Songül Alpaslan-Roodenberg
    • David Reich
    Research
    Nature
    Volume: 555, P: 197-203

  • Whole-genome bisulfite sequencing along with whole-genome and transcriptome sequencing of 100 prostate cancer metastases identifies genomic regions that are differentially methylated during disease progression and a novel epigenomic subtype.

    • Shuang G. Zhao
    • William S. Chen
    • Felix Y. Feng
    Research
    Nature Genetics
    Volume: 52, P: 778-789

  • Statistical analyses of a metagenomics-sequenced human cohort identify a relatively minor role for genetics in determining microbiome composition and show that several human phenotypes are as strongly associated with the gut microbiome as with host genetics.

    • Daphna Rothschild
    • Omer Weissbrod
    • Eran Segal
    Research
    Nature
    Volume: 555, P: 210-215