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Showing 1–3 of 3 results
Advanced filters: Author: Aditi Gnanasekar Clear advanced filters

  • A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing cells and persist across generations.

    • Venkat Sankar
    • King L. Hung
    • Howard Y. Chang
    ResearchOpen Access
    Nature
    Volume: 649, P: 152-160

  • The impact of breakage fusion bridge (BFB) cycles on tumour heterogeneity and clinical outcomes remains poorly understood. Here, the authors develop OM2BFB, an algorithm to detect and reconstruct BFB amplifications using optical genome maps and use it to study BFB events across 2557 primary tumours and cancer cell lines.

    • Siavash Raeisi Dehkordi
    • Ivy Tsz-Lo Wong
    • Vineet Bafna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19