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Showing 1–7 of 7 results
Advanced filters: Author: Aditya M. Kunjapur Clear advanced filters

  • Gene synthesis has expanded the ability to modify and create DNA sequences, with implications for biosurveillance. The authors use machine learning and codon theory to identify synthetic genes in Addgene data, and show that synthesis accelerates human-directed gene transfer across the tree of life.

    • Aditya M. Kunjapur
    • Philipp Pfingstag
    • Neil C. Thompson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • A combination of enzyme discovery for nonheme diiron N-monooxygenases, metabolic engineering and genetic code expansion enables the construction of a live bacterial producer of synthetic nitrated proteins containing para-nitro-l-phenylalanine.

    • Neil D. Butler
    • Sabyasachi Sen
    • Aditya M. Kunjapur
    Research
    Nature Chemical Biology
    Volume: 19, P: 911-920

  • Microbial pathways can be engineered for the sustainable production of chemical products such as transportation fuels. Here the authors design and implement a de novo biosynthetic pathway in E. colithat is capable of producing the gasoline replacement, 4-methyl-pentanol.

    • Micah J. Sheppard
    • Aditya M. Kunjapur
    • Kristala L. J. Prather
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • This Primer by Wannier and colleagues summarizes the methodology, analysis and utility of recombineering and multiplex automated genome engineering (MAGE) in microbial species. In addition, this Primer examines advanced techniques that pair MAGE with other tools to improve editing efficiency.

    • Timothy M. Wannier
    • Peter N. Ciaccia
    • George M. Church
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-24