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Showing 1–4 of 4 results
Advanced filters: Author: Adrian Salic Clear advanced filters

  • Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex with lipid-modified Sonic hedgehog (Shh), with insights into the mechanisms of hDisp1 activation and function.

    • Wanqiu Li
    • Linlin Wang
    • Xin Gong
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Haematopoietic stem cells (HSCs) have a lower rate of protein synthesis in vivo than most other haematopoietic cells, and both increases and decreases in the rate of protein synthesis impair HSC function, demonstrating that HSC maintenance—and hence, cellular homeostasis—requires the rate of protein synthesis to be highly regulated.

    • Robert A. J. Signer
    • Jeffrey A. Magee
    • Sean J. Morrison
    Research
    Nature
    Volume: 509, P: 49-54

  • A Xenopus laevis two-reporter screen identifies the antihelminthic drug pyrvinium as an inhibitor of the Wnt/β-catenin signaling pathway that works by activating CK1α, which is likely working at the level of Pygopus, a core transcriptional component of the Wnt pathway.

    • Curtis A Thorne
    • Alison J Hanson
    • Ethan Lee
    Research
    Nature Chemical Biology
    Volume: 6, P: 829-836