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Showing 1–4 of 4 results
Advanced filters: Author: Adrian W. Hodel Clear advanced filters

  • Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes). Here authors show that two mechanisms protect the membranes of CTLs from disruption by perforin and granzymes.

    • Jesse A. Rudd-Schmidt
    • Adrian W. Hodel
    • Ilia Voskoboinik
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to identify the kinetic bottleneck of MAC formation.

    • Edward S. Parsons
    • George J. Stanley
    • Bart W. Hoogenboom
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Perforin monomers self-assemble into pre-pores that first insert into the membrane and then recruit additional subunits to grow in size.

    • Carl Leung
    • Adrian W. Hodel
    • Bart W. Hoogenboom
    Research
    Nature Nanotechnology
    Volume: 12, P: 467-473

  • Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors present structures of hexadecameric MPEG1 prepores both in solution and in complex with liposomes.

    • Siew Siew Pang
    • Charles Bayly-Jones
    • James C. Whisstock
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9